Background: Many publications discussed the potential role of medicinal plants in the management of COVID-19. However, clinical studies of the efficacy and safety of specified phytochemical(s) are limited. Objectives: To explore the pharmacological profile of specified compounds...
Open access
Research Article10.9734/jpri/2021/v33i53B33678
Ahmed S. Ali, Mahran S. Abdel-Rahman, Riyadh S. Almalikil, Abir S. Mohamed, Khalid A. Alfaifi, Abdelbabgi El. Fadil, Nagla A. El-Shitany & Huda M. Alkreathy·Journal of Pharmaceutical Research International·2020
After the global pandemic of the new coronavirus, its rapid spread and many victims, it is necessary to find an effective vaccine or drugs to overcome it. Most specialists consider that repositioning some medications is the best, fastest and most reliable option for treating pati...
Open access
Research Article10.9734/jpri/2020/v32i830468
Objectives: To study the effect of concomitant administering of pomegranate juice orally (PJ) on bioavailability of cyclosporine A (CsA) and independently its potential nephroprotective effect against CsA induced nephrotoxicity. Methods: A- Pharmacokinetic study (PK), Wister rats...
Open access
Research Article10.9734/jpri/2018/v25i330103
Tacrolimus (Fk506)- based immunosuppressant regimen has become the cornerstone in managing kidney transplant patients (KTP) , where it has been used typically used on chronic basis. However, various adverse effects on multiple organ systems are expected and their incidence is dep...
Open access
Research Article10.9734/JPRI/2018/41611
Abdelbagi Elfadil, Ahmed S. Ali, Mohammad W. Alrabia, Hamoud Alsamhan, Hind Abdulmajed, Ibrahim Ismail Mohammed Abu, Mohammad Allibaih & Khalid Hussein Bakheit Ahmed·Journal of Pharmaceutical Research International·2023
Background: 2,3-dimethylquinoxaline (DMQ) is a naturally occurring compound with documented antifungal activity. It showed also good in vitro physicochemical and pharmacokinetic characteristics. Methods: The wound healing activity of 1% DMQ hydrogel in healthy adult male Wister r...
Open access
Research Article10.9734/jpri/2023/v35i87339
Aims: To explore the antifungal activity of 2,3-dimethylquinoxaline. Study Design: A preclinical study of a compound against 10 fungal species. Backgrounds: Severe fungal infections cause significant clinical problem and need more effort to search for new antifungals. Methodology...
Open access
Research Article10.9734/jpri/2021/v33i31A31684
Aims: In numerous cases, patients with inflammatory bowel diseases (IBDs) are refractory to standard treatment. Sirolimus (SIR) and tacrolimus (TAC) are immunosuppressant drugs with encouraging outcomes. However, they have side effects causing limitations in their use. Metformin...
Open access
Research Article10.9734/jpri/2020/v32i1030496