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Amara A. Ajaghaku

Publications (2)

Neuroprotective and Cognitive-Enhancing Effects of a Phytoestrogen Rich Fraction from Ochna schweinfurthiana Bark in a Rat Model of Menopause and Cholinergic Dysfunction

Daniel L. Ajaghaku, Paul Chinwuba & Amara A. Ajaghaku · Asian Journal of Research in Medical and Pharmaceutical Sciences · 2025

In postmenopausal women, a substantial decrease in circulating estrogen levels has been strongly associated with an increased risk of cognitive dysfunction. Both clinical and preclinical studies have demonstrated that estrogen positively affects synaptic plasticity, hippocampal n...

Open access Research Article 10.9734/ajrimps/2025/v14i3340

Synergistic Effects of Polyphenol-Terpenoid Combinations on NLRP3 Inflammasome-Mediated Neuroinflammation: A Mini Review

Paul Chinwuba, Chimaobi O. Ugorji, Daniel L. Ajaghaku, Winifred O. Amattah, Amara A. Ajaghaku, Onyesife C. Obiageli, Zogini U. Confidence, Victor T. Ezeifeh & Okoro O. Kingsley · Journal of Pharmaceutical Research International · 2025

Neuroinflammation driven by the NLRP3 inflammasome is a key mechanism in many neurological disorders. While plant-derived polyphenols and terpenoids individually show anti-inflammatory potential, their synergistic effects remain underexplored. This review highlights the enhanced...

Open access Research Article 10.9734/jpri/2025/v37i117762