Dani T. Mawete

In Silico ADME/T Properties of Quinine Derivatives using SwissADME and pkCSM Webservers

Jean Gonfi M. Mvondo, Aristote Matondo, Dani T. Mawete, Sylvie-Mireille N. Bambi, Blaise M. Mbala & Pierre O. Lohohola · International Journal of TROPICAL DISEASE & Health · 2021

Aim: Malaria is among the most devastating and widespread tropical parasitic diseases. To overcome antimalarial drug resistance, new drugs need to be developed. This study is designed to establish the pharmacokinetic profile and toxicity of nine quinine derivatives as potential a...

Open access Research Article 10.9734/ijtdh/2021/v42i1130492

Facing COVID-19 Via Anti-Inflammatory Mechanism of Action: Molecular Docking and Pharmacokinetic Studies of Six Anti-Inflammatory Compounds Derived from Passiflora edulis

Aristote Matondo, Jason T. Kilembe, Domaine T. Mwanangombo, Beaudrique M. Nsimba, Dani T. Mawete, Benjamin Z. Gbolo, Gédéon N. Bongo, D. O. Opota, Koto-Te-Nyiwa Ngbolua, Dorothée D. Tshilanda, Damien S. T. Tshibangu, Virima Mudogo & Pius T. Mpiana · Journal of Complementary and Alternative Medical Research · 2021

Aim: In the most severe case of the COVID-19, there is an excessive production of proinflammatory cytokines, being the main cause of mortality and morbidity. The present study aims at assessing the potential inhibitor effect of six phytochemicals with anti-inflammatory activity d...

Open access Research Article 10.9734/jocamr/2020/v12i330211