Deto Ursul Jean-Paul N’guessan

Synthesis, Antifungal Evaluation, and Structure–activity Relationship of Chlorinated Imidazopyridinyl- phenylpropenone Derivatives against Aspergillus fumigatus

Deto Ursul Jean-Paul N’guessan, Songuigama Coulibaly, Avi Tanguy Kouao, Alain A. Kacou, Kpongbo Etienne Angora, Fabrice Koffi, Ismaila Diallo & Mahama Ouattara · Chemical Science International Journal · 2025

Background: Aspergillus fumigatus is the leading causative agent of invasive aspergillosis, a deadly opportunistic fungal infection in immunocompromised patients. The increasing emergence of azole-resistant strains necessitates the urgent development of new antifungal molecules....

Open access Research Article 10.9734/CSJI/2025/v34i61011

Synthesis and Anticandidal Activity of New 6-Chloroimidazo[1,2-a]pyridine Derivatives

Deto Ursul Jean-Paul N’guessan, Songuigama Coulibaly, Alain A. Kacou, Kpongbo Etienne Angora, Fabrice Koffi & Mahama Ouattara · Asian Journal of Chemical Sciences · 2025

Aims: The general objective assigned to this work was to contribute to the pharmacochemical development of new antifungal drugs derived from 6-Chloroimidazo [1,2-a]pyridine.This preliminary study was conducted on Candida parapsilosis, which is an increasingly difficult organism t...

Open access Research Article 10.9734/ajocs/2025/v15i3371

Synthesis and Antifungal Activity of 6-Chloroimidazo[1,2-a]pyridinyl-Chalcones Against Aspergillus Flavus

Songuigama Coulibaly, Deto Ursul Jean-Paul N’guessan, Kouaho Avi kadjo Tanguy, Alain A. Kacou, Kpongbo Etienne Angora, Fabrice Koffi & Mahama Ouattara · Asian Journal of Chemical Sciences · 2025

Aims: This pharmacochemical study aimed to design, synthesize, structurally characterize, and evaluate the anti-aspergillus activity of a new series of 6-chloroimidazo[1,2-a]pyridinyl–chalcone derivatives against an environmental strain of Aspergillus flavus, a major opportunisti...

Open access Research Article 10.9734/ajocs/2025/v15i6415