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Djako Akassa Marius Bernard

Publications (4)

Identification of Novel Polyketide Synthase 13 of Mycobacterium Tuberculosis Inhibitors: A Modelling Approach Using the Pharmacophore Method -Based Virtual Screening

Djako Akassa Marius Bernard, Niaré Adama, Fofana Issouf, Moussé Logbo Mathias, Kéita Mélalie & Megnassan Eugène · Journal of Advances in Medical and Pharmaceutical Sciences · 2025

Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. It remains a major public health problem worldwide. In 2022, 10.6 million people contracted tuberculosis and 1.3 million died from it.  This manuscript presents our work, the aim of which is to find new i...

Open access Research Article 10.9734/jamps/2025/v27i6784

Computer-assisted Design of Novel Polyketide Synthase 13 of Mycobacterium tuberculosis Inhibitors Using Molecular Modeling and Virtual Screening

Djako Akassa Marius Bernard, Melalie Keita, Yvon Bibila Mayaya Bisseyou, Akori Esmel & Eugene Megnassan · Journal of Pharmaceutical Research International · 2022

Aims: Polyketide synthase 13 (Pks13) is an essential enzyme in the synthesis of mycolic acids biosynthesis pathway of Mycobacterium tuberculosis (Mtb). Therefore, Pks13 is a promising drug target for tuberculosis treatment. Here we report the in silico design and evaluation of no...

Open access Research Article 10.9734/jpri/2022/v34i567250

Molecular Modeling and Virtual Screening: Application to Computer-Aided Design of Anticancer Inhibitors of Human Dihydroorotate Dehydrogenase

N’doman Gossan Roméo, Bibila Mayaya Bisseyou Yvon, Djako Akassa Marius Bernard, Niaré Adama, Akori Esmel Elvice, Kéita Mélalie & Megnassan Eugène · Journal of Pharmaceutical Research International · 2025

Abnormal and uncontrolled cell growth leading to dysfunction of cellular metabolism causes a serious disease called cancer. In 2022, 20 million people had cancer and 9.7 million died. Cancer is a real health problem given the number of deaths caused by this disease. This article...

Open access Research Article 10.9734/jpri/2025/v37i87734

Study by Molecular Docking of the Interactions between Dihydroorotate Dehydrogenase and a Series of Inhibitors of Pyrrole Derivatives for the treatment of Malaria

Niaré Adama, Attia Yapo John Alex, Djako Akassa Marius Bernard, Kambiré Sobamfou Marius, Dembélé Georges Stéphane, Kouadio Assandé Moise, Koné Mamadou Guy-Richard, Yves Kily Hervé Fagnidi & Soro Doh · Asian Journal of Chemical Sciences · 2025

Malaria, although a curable disease, continues to be the most important infectious disease in terms of incidence and mortality worldwide. It is a potentially fatal disease caused by parasites transmitted to people through the bites of infected female Anopheles mosquitoes. This di...

Open access Research Article 10.9734/ajocs/2025/v15i1352