The improved synthesis of Flecainide acetate (I) is conferred in this article. The chief intent to present this article is to identify and synthesis of the process related impurities of Flecainide acetate. The article also provides the complete study and characterization of the p...
Open access
Research Article10.9734/jpri/2022/v34i47A36401
The article confers a scalable manufacturing process of Fenspiride HCl. 4-aminomethyl-1-(2-phenylethyl)-piperidin-4-ol is the main building block in Fenspiride HCl synthesis. The reported reagents for 4-aminomethyl-1-(2-phenylethyl)-piperidin-4-ol synthesis are costly, explosive,...
Open access
Research Article10.9734/jpri/2021/v33i51B33523
An improved and simplified process of vitamin K1 preparation. The article confers the new reagent BF3. Acetic acid complex as a condensation reagent for phytol with compound III in vitamin K1 synthesis, which eludes the use of ethereal reagent and make the process hazard free. Fu...
Open access
Research Article10.9734/jpri/2021/v33i47B33153
Commercially viable manufacturing process for Flecainide Acetate (I) conforming to regulatory specification and cost effective process is reported. Specifically, an improved process for the preparation of Flecainide Acetate allows isolation of anhydrous hydrochloride salt of Comp...
Open access
Research Article10.9734/jpri/2021/v33i46A32885
A simple, rapid, selective, and reproducible Gas chromatographic mass spectrometry (GC-MS) method has been developed and validated for the estimation of Diethyl Phosphite content in Foscarnet Sodium USP Drug substance. The drugs were estimated using HP-5, Length-30 M, Internal di...
Open access
Research Article10.9734/jpri/2021/v33i46A32857
The measurement of Genotoxic contaminant, a simple, selective, linear, accurate, and specific reverse phase high-performance liquid chromatographic (RP-HPLC) process was proposed. A Benzimidamide impurity in the medication Leflunomide has been discovered. Separation and analysis...
Open access
Research Article10.9734/jpri/2021/v33i45B32782