José A. Stoute

Association between Sickle Cell Trait and Low Density Parasitaemia in a P. falciparum Malaria Holoendemic Region of Western Kenya

Walter Otieno, Benson B. A. Estambale, Joash R. Aluoch, Stacey M. O. Gondi & José A. Stoute · International Journal of TROPICAL DISEASE & Health · 2012

Aims: The frequency of the mutant gene for sickle cell is widely distributed in the sub-Saharan Africa, the Middle East, and the Indian subcontinent. There is epidemiologic evidence that sickle cell trait confers a survival advantage against malaria and that the selection pressur...

Open access Research Article 10.9734/IJTDH/2012/1762

Sickle Cell Trait (HbAS) is Associated with Increased Expression of Erythrocyte Complement Regulatory Proteins CR1 and CD55 Levels in Children

Walter Otieno, Benson B. A. Estambale, Michael M. Odera, Stacey M. O. Gondi, Joash R. Aluoch & José A. Stoute · International Journal of TROPICAL DISEASE & Health · 2013

Aims: Erythrocyte complement regulatory proteins, complement receptor 1 (CR1) and decay accelerating factor (CD55) protect red blood cells (RBCs) from complement mediated damage by controlling complement activation cascade and potentially protect RBCs from complement mediated dam...

Open access Research Article 10.9734/IJTDH/2013/2948

Increased Complement Deposition on Red Blood Cells in Children with Sickle Cell Trait

Walter Otieno, Benson B. A. Estambale, Michael M. Odera, Collins O. Odhiambo, Joash R. Aluoch, Bernard Guyah, Stacey M. O. Gondi & José A. Stoute · Journal of Advances in Medicine and Medical Research · 2014

Aims: Immune-mediated mechanism, such as deposition of complement (C3b) on erythrocytes leading to enhanced receptor-mediated uptake by macrophages has been proposed to contribute partly to the destruction of non-infected cells leading to anaemia. The extent of complement deposit...

Open access Research Article 10.9734/BJMMR/2015/9438