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Joshua Charles Isirima

Publications (7)

Effect of Aqueous Cinnamon Bark Extract on Inflammatory Protein Biomarkers in Cadmium-exposed Wistar Rats

Joshua Charles Isirima & Naomi Akpevwe Mogborukor · International Journal of Biochemistry Research & Review · 2026

Background and Aims: Cadmium exposure can induce oxidative and inflammatory disturbances. This study investigated the therapeutic potential of cinnamon extract for modulating cadmium-induced inflammation in Wistar rats. The experimental design involved inducing inflammation in Wi...

Open access Research Article 10.9734/ijbcrr/2026/v35i51161

Effect of Acalypha wilkesiana on Oxidative Stress and Histopathology of Liver and Kidney in Alloxan-induced Diabetic Albino Rats

Joshua Charles Isirima & Precious Ojo Uahomo · Journal of Complementary and Alternative Medical Research · 2023

This study investigated the effect of Acalypha wilkesiana on oxidative stress biomarkers as well as liver and kidney histopathology. 54 Albino rats were divided into 6 groups of 9 animals each including group 1 animals received only feed and water ad libitum; group 2 received 160...

Open access Research Article 10.9734/jocamr/2023/v22i4463

Attenuating Ketamine-Induced Nephrotoxicity with Bryophyllum pinnatum Extract: Biochemical and Histological Investigation

Precious Ojo Uahomo & Joshua Charles Isirima · Journal of Complementary and Alternative Medical Research · 2025

Background: Ketamine, a widely used anesthetic agent, has been shown to induce nephrotoxicity, characterized by increased kidney function markers and structural damage. Despite its therapeutic applications, the adverse effects of ketamine on the kidneys necessitate the exploratio...

Open access Research Article 10.9734/jocamr/2025/v26i1612

Neuroprotective Effects of Bryophyllum pinnatum against Ketamine-Induced Neurotoxicity in Wistar Rats: Neurochemical, Oxidative Stress, and Histological Investigation

Precious Ojo Uahomo & Joshua Charles Isirima · International Neuropsychiatric Disease Journal · 2024

Background: This study evaluated the neuroprotective effects of Bryophyllum pinnatum (B. pinnatum) in ketamine-induced neurotoxicity in Wistar rats, focusing on neurochemical and oxidative stress markers, as well as histological changes in the hippocampus and cerebral cortex. Met...

Open access Research Article 10.9734/indj/2024/v21i6452

Cardisoma guanhumi as a Therapeutic Candidate: Assessing Hypo-lipidemic and Histological Effects in Bordetella pertussis Infected Swiss Mice

Enyi, Ikpechi Ovundah & Joshua Charles Isirima · Journal of Complementary and Alternative Medical Research · 2023

Background: Bordetella pertussis is the causative organism of an acute human respiratory tract disease known as pertussis – an endemic disease globally with reported cases in both developing and developed countries. This study evaluated the hypo-lipidaemic and histological effect...

Open access Research Article 10.9734/jocamr/2023/v23i4484

Preventive Effects of Traditional Plant Concoction “Combo” on the Cyclophosphamide-Induced Ovarian Toxicity in Wistar Rats

Dorcas Okayo Okoroafor & Joshua Charles Isirima · Asian Journal of Research in Medical and Pharmaceutical Sciences · 2023

Exposure to chemotherapeutic agents like cyclophosphamide (a drug for cancer treatment), leads to infertility due to its toxic effect on the ovaries.  Combo, “a commonly used plant concoction in traditional medicine for the treatment of infertility” is composed of Clove (dried fl...

Open access Research Article 10.9734/ajrimps/2023/v12i2213

Evaluation of Phytochemicals and Bioactive Properties in Leaf and Root Parts of Cyathula prostrata (Pasture Weed) – A Qualitative and Quantitative Analysis

Precious Ojo Uahomo, Joshua Charles Isirima & Sokiprim Akoko · Asian Plant Research Journal · 2022

Cyathula prostrata (Blume) L, a member of the Amaranthaceae family, has long been used in tropical regions of the world for a variety of diseases, and study has shown that it is beneficial in the treatment of rheumatism, dysentery, wounds, and urethral discharges. The goal of thi...

Open access Research Article 10.9734/aprj/2022/v9i330207