M. L. Lucas

Comparison of the Effects of E. coli STa with E. coli LT, Clostridium difficile Toxin A and Osmotic Burdens on Small Intestinal Fluid Transport: Additional Proof that STa is Not a Secretory Enterotoxin

M. L. Lucas, S. Frame, S. Wheeler, A. H. Currie, A. Sheidaee, S. M. Reza, S. Fee, G. Li, C. J. R. Turkington & E. McNaughton · Journal of Advances in Medicine and Medical Research · 2018

Using a recirculation procedure to perfuse anaesthetised rat jejunum, E. coli STa enterotoxin can be shown to inhibit net fluid absorption profoundly, while not causing net fluid secretion, provided fluid measurement is by mass or volume. This observation contradicts many reports...

Open access Research Article 10.9734/JAMMR/2018/44118

Reduction in Jejunal Fluid Absorption In vivo through Distension and Cholinergic Stimulation Not Attributable to Enterocyte Secretion

M. L. Lucas, H. L. Kenward, P. C. Watson, S. R. Sabir, C. J. R. Turkington, P. Tainsh, S. McColl, V. S. Graham & E. McNaughton · Journal of Advances in Medicine and Medical Research · 2018

Jejunal fluid absorption in vivo was reduced by distension and by hydrostatic pressure and further declined on adding E. coli STa enterotoxin but no net fluid secretion was detected. Luminal atropine reduced pressure mediated reductions in fluid absorption to normal values but in...

Open access Research Article 10.9734/JAMMR/2018/39184