Background: The pathogenesis and effects of maternal diabetes on their infants is still not entirely understood, but it's likely to have several teratogenic mechanisms. The fetal heart is anatomically and physiologically altered by diabetes mellitus. About 400 genes are thought t...
Open access
Research Article10.9734/ajpr/2022/v8i130236
Aims: Gaucher disease "GD" is one of the most common glycolipid storage disorders. Several circulating molecules thought to be secreted by Gaucher cells have been studied as biological markers of disease. We investigate and compare the validity of using plasma chitotriosidase "Ch...
Open access
Research Article10.9734/IJBCRR/2017/32782
Aims: We evaluate the effect of enzyme replacement therapy "ERT" on the plasma levels of some biochemical markers of the disease burden, in pediatric patients with Gaucher's disease "GD", in the form of plasma chitotriosidase "ChT", total acid phosphatase activity, ferritin and g...
Open access
Research Article10.9734/IJBCRR/2016/30768
Aims: Inborn errors of metabolism (IEM) constitute a group of inherited disorders that cause significant morbidity and mortality. This diverse group of diseases present with different clinical manifestations that make the diagnosis a real challenge. The current work aimed to inve...
Open access
Research Article10.9734/IJBCRR/2016/31021
Background and Objectives: Type 1 Diabetes mellitus (T1DM) is a disorder of glucose homeostasis results from the destruction of β- cells of the pancreas with subsequent insulin deficiency and hyperglycemia. Acquired mutation (V617F) affecting the JAK2 gene disrupts the auto-inhib...
Open access
Research Article10.9734/ajbgmb/2020/v4i130096
Background: It is important to identify patients at risk of developing cardiovascular events to enable preventive interventions and promote lifestyle modifications. Carotid intima–media thickness (CIMT) is an important marker for cardiovascular disease and can be easily measured...
Aims: To assess the relation between the grade of steatosis and anthropometric measures, lipid profile and serum adiponectin in non-diabetic patients with nonalcoholic fatty liver. Study Design: Cross sectional study. Place and Duration of Study: Department of Tropical Medicine a...
Open access
Research Article10.9734/BJMMR/2015/16594
CNS traumas and tumors are major health problems. They lead to serious health and economic burdens. They are major causes of disability, or death all over the world. Nowadays, the order of causes of trauma-related death has beenchanged from multiorgan affection to CNS trauma. Ass...
Open access
Research Article10.9734/ajbgmb/2022/v11i230260
Vitiligo is an acquired skin disorder that is characterized by a gradual loss of skin pigmentation when melanocytes, the skin's pigment-producing cellsis lost. Pathogenicmechanisms are not well understood. Genetic, abnormal biochemical pathways, autoimmune, melanocyte adhesion de...
Open access
Research Article10.9734/ajbgmb/2021/v8i230189
Aims: Certain liver diseases can cause decreased synthesis of liver proteins or enzymes, including biotinidase, thereby reducing biotinidase activity in serum. The present study aimed to assess plasma biotinidase level in pediatric patients with compensated and decompensated chro...
Open access
Research Article10.9734/IJBCRR/2017/32764