Mutaib M. Mashraqi

Properdin: An Immune System Regulator That Can Be a Therapeutic Target of the Complement System

Mutaib M. Mashraqi & Saeed A. Asiri · Journal of Pharmaceutical Research International · 2022

Properdin, a serum glycoprotein, is involved in the immune system regulation, particularly in alternative pathways beginning the complement system. Properdin is made up of cyclic oligomers of monomeric subunits and is generated by various leukocyte subsets. Properdin promotes com...

Open access Research Article 10.9734/jpri/2022/v34i31A36080

Computational Screening of Natural Compounds for the Discovery of Potential Aromatase Inhibitors: A Promising Therapy for Estrogen-Dependent Breast Cancer

Misbahuddin M. Rafeeq, Ziaullah M. Sain, Norah A. Alturki, Ahmad Alzamami, Saeed A. Asiri, Mutaib M. Mashraqi, Amany I. Alqosaibi, Mashael M. Alnamshan, Abdulrahman Almutairi, Abdulkhaliq Munawir Alanazi & Qamre Alam · Journal of Pharmaceutical Research International · 2021

Aromatase plays a significant role in the progression of estrogen receptor-positive (ER-positive) breast cancer. The adverse side effects of currently used aromatase inhibitors (AIs) necessitate the development of new AIs that are more active, selective, and less toxic. This stud...

Open access Research Article 10.9734/jpri/2021/v33i32A31717