Nathaniel K. Howard

Nonparametric Stepwise Procedure for Identification of Maximum Safe Dose (MSD)

Michael J. Adjabui, Nathaniel K. Howard & Albert Luguterah · Asian Research Journal of Mathematics · 2017

In this article we consider identification of maximum safe dose (MSD) in a dose response study for distribution-free endpoints. Where the maximum safe dose is the highest dose level that does not exceed the median toxicity of the zero dose by a predetermined margin. A nonparametr...

Open access Research Article 10.9734/ARJOM/2017/36377

Stepwise Procedure for Toxicological Assessment Based on Ratio of Mean Differences for a Normally Distributed Data

Michael J. Adjabui, Jakperik Dioggban & Nathaniel K. Howard · Asian Research Journal of Mathematics · 2021

We propose a new stepwise confidence set procedure for toxicity study based on ratio of mean difference. Statistical approaches for evaluating toxicity studies that properly control familywise error rate (FWER) for difference of means between treatments and a control already exis...

Open access Research Article 10.9734/arjom/2021/v17i1130341