Niaré Adama, Attia Yapo John Alex, Djako Akassa Marius Bernard, Kambiré Sobamfou Marius, Dembélé Georges Stéphane, Kouadio Assandé Moise, Koné Mamadou Guy-Richard, Yves Kily Hervé Fagnidi & Soro Doh·Asian Journal of Chemical Sciences·2025
Malaria, although a curable disease, continues to be the most important infectious disease in terms of incidence and mortality worldwide. It is a potentially fatal disease caused by parasites transmitted to people through the bites of infected female Anopheles mosquitoes. This di...
Open access
Research Article10.9734/ajocs/2025/v15i1352
We virtually design here new subnanomolar range antimalarial, inhibitors of plasmodium falciparum M1 Aminopeptidase (PfA-M1), by means of structure-based molecular design. We developed the complexation QSAR models from Hydroxamic Acid derivatives (AHO). A linear correlation was e...
Open access
Research Article10.9734/jpri/2022/v34i607271
Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. It remains a major public health problem worldwide. In 2022, 10.6 million people contracted tuberculosis and 1.3 million died from it. This manuscript presents our work, the aim of which is to find new i...
Open access
Research Article10.9734/jamps/2025/v27i6784
Stabilization of enzymes is crucial to improve their durability and efficiency in various industrial applications. Thus, the search for new thermostable enzymes is a booming field. The seeds of Artocarpus communis are rich in acid phosphatases. Study of these enzymes could also b...
Open access
Research Article10.9734/bji/2025/v29i2770
Issouf Soro, Manchondenin Soro, Ludovic Akonan, Niaré Adama, Boris Davy Bekono, Raymond Kre N’guessan & Eugene Megnassan·Asian Journal of Chemical Sciences·2026
Alzheimer’s disease (AD) is a neurodegenerative disorder associated with cholinergic dysfunction, and butyrylcholinesterase (BuChE) becomes increasingly relevant as disease pathology progresses. This study aimed to design sulfenylated 5-aminopyrazole (APS) analogues as potential...
Open access
Research Article10.9734/ajocs/2026/v16i5478
N’doman Gossan Roméo, Bibila Mayaya Bisseyou Yvon, Djako Akassa Marius Bernard, Niaré Adama, Akori Esmel Elvice, Kéita Mélalie & Megnassan Eugène·Journal of Pharmaceutical Research International·2025
Abnormal and uncontrolled cell growth leading to dysfunction of cellular metabolism causes a serious disease called cancer. In 2022, 20 million people had cancer and 9.7 million died. Cancer is a real health problem given the number of deaths caused by this disease. This article...
Open access
Research Article10.9734/jpri/2025/v37i87734
Over the past decade, drug resistance has emerged as a major challenge in the treatment of high blood pressure. This report evaluates new imidazo[4.5-c]pyridin-4-one compounds designed to inhibit the AT1 enzyme, and highlights their therapeutic potential, supported by favourable...
Open access
Research Article10.9734/jpri/2026/v38i57837