Nishanth Kumar Nagamalli

Sustained-Release Ophthalmic Drug Delivery Systems: An Updated Review of Innovations, Current Trends and Future Prospects

Chinna Reddy Palem, Vamshi Krishna Lekkala, Nishanth Kumar Nagamalli, Paidi Venkata Santhosh, Prasant Noolu & Sridhar Gumudevelli · Ophthalmology Research: An International Journal · 2026

Background & Scope: Ocular drug delivery is inherently limited by anatomical and physiological barriers such as rapid tear turnover, blinking, nasolacrimal drainage, and restricted corneal permeability. These protective mechanisms substantially reduce drug residence time and...

Open access Research Article 10.9734/or/2026/v21i2506

Comparative Evaluation of Floating and Non-Floating Controlled-release Metformin HCl Tablets: In vitro and In vivo Characterization

Chinna Reddy Palem, Prasant Noolu, Praveen Rao Balguri, Nishanth Kumar Nagamalli & Sridhar Gumudevelli · Asian Journal of Research in Medical and Pharmaceutical Sciences · 2026

Objective: The present study aimed to comparatively evaluate floating and non-floating controlled-release formulations of Metformin HCl to understand the influence of formulation composition and processing variables on gastroretentive behavior, drug release characteristics, and p...

Open access Research Article 10.9734/ajrimps/2026/v15i2377

A Metered-dose Inhalers in the Modern Era: Technologies, Challenges, Industrial Insights and Future Directions

Chinna Reddy Palem, Vamshi Krishna Lekkala, Venkata Santhosh Paidi, Nishanth Kumar Nagamalli, Deepthi Battula, Ravindar Rendla, Praveen Rao Balguri & Sridhar Gumudevelli · Journal of Pharmaceutical Research International · 2025

Scope and Objective: Metered-dose inhalers (MDIs) remain the cornerstone of inhalation therapy for asthma and chronic obstructive pulmonary disease (COPD), offering a portable, efficient, and cost-effective means of delivering drugs directly to the lungs. The global MDI market is...

Open access Research Article 10.9734/jpri/2025/v37i127778

Design and Evaluation of Controlled-Release Floating Metformin HCl Tablets: Influence of Binder and Granulation Process on Buoyancy

Chinna Reddy Palem, Prashant Noolu, Varun Chilukoti, Praveen Rao Balguri, Nishanth Kumar Nagamalli & Sridhar Gumudevelli · Journal of Pharmaceutical Research International · 2025

Scope and objective: Objective of this study is to investigate how the combined effects of binder properties and granulation parameters shape the development and performance of controlled-release floating Metformin HCl tablets. It focuses on evaluating the suitability of various...

Open access Research Article 10.9734/jpri/2025/v37i127795