Background: Chromobacterium violaceum (C. violaceum), a Gram-negative, facultative anaerobic, non-sporing coccobacillus has a quorum-sensing system consisting of CviI/CviR, a homologous gene. Quorum sensing (QS) is a mechanism of intercellular communication in bacteria that recei...
Open access
Research Article10.9734/jpri/2021/v33i48B33284
Background: Pseudomonas aeruginosa is a Gram-negative opportunistic human pathogen that mainly infects immunocompromised individuals and patients with urinary tract infection and chronic infections of the respiratory pathways, including cystic fibrosis. Many quorum sensing (QS) c...
Open access
Research Article10.9734/jpri/2021/v33i47B33180
Background : Hepatitis B is a potentially life-threatening liver infection caused by the Hepatitis B virus (HBV). It is a major global health problem and the most serious type of viral hepatitis. It can cause chronic liver disease and puts people at high risk of death from cirrho...
Open access
Research Article10.9734/jpri/2021/v33i47B33141
Background: Acinetobacter baumannii is typically short, rod shaped gram negative bacterium. The World Health Organisation has declared it as an opportunistic pathogen in humans. Multi drug resistance involves different genetic determinants making the pathogen difficult to treat....
Open access
Research Article10.9734/jpri/2021/v33i60B35076
Background: Acinetobacter baumannii is a gramnegative bacilli acquiring both intrinsic and adaptive patterns of multi drug resistance and virulence. Immune-informatics approach holds promise to detect putative epitope peptides from vital virulence factors which can be further syn...
Open access
Research Article10.9734/jpri/2021/v33i58B34228
Background: Acinetobacter baumannii is an opportunistic bacterial pathogen that is primarily associated with hospital-acquired infections. Recently, there is a dramatic increase in the incidence of multidrug-resistant (MDR) strains, which has significantly raised the profile of t...
Open access
Research Article10.9734/jpri/2021/v33i58B34213
Background: A.baumannii is an opportunistic pathogen known for its efficient biofilm formation that is attributed for its virulence. Acinetobacter baumannii is an inhabitant of oral biofilms as well. Many gene operons are involved in the biofilm formation that need to be monitore...
Open access
Research Article10.9734/jpri/2021/v33i57B34062
Introduction: Acinetobacter baumannii is a gram negative coccobacilli often considered as a nosocomial pathogen and as an opportunistic pathogen in immunocompromised patients. It is considered to be multi-drug resistant and a potent bacteria forming vital biofilms. Ptk which is p...
Open access
Research Article10.9734/jpri/2021/v33i58A34093
Background: Acinetobacter baumannii is a Gram-negative bacillus that is aerobic, pleomorphic and non-motile. Multi-drug resistance and biofilm formation contributes to the virulence and pathogenicity of the bacterium. Among many virulence factors, csuE is critical for initiation...
Open access
Research Article10.9734/jpri/2021/v33i58A34096
Background: Acinetobacter baumannii is a coccobacillus that is Gram negative, non motile, non fermentative and oxidase negative. It is the most common and successful nosocomial pathogen recognised by WHO. This dreadful pathogen causes urinary tract infections, ventilator associat...
Open access
Research Article10.9734/jpri/2021/v33i58A34099
Background: Acinetobacter baumannii is a gram-negative bacterium classified as an opportunistic pathogen in humans by the World Health Organization. Different genetic determinants contribute to multidrug resistance, and transform it as a nosocomial pathogen. Aim: Using in-silico...
Open access
Research Article10.9734/jpri/2021/v33i48B33282
Background: Acinetobacter baumannii is a gram negative bacterium which is typically short, round, coccobacillus and was named after the bacteriologist Paul Baumann. It is an emerging dental pathogen since it acquires drug resistance and expression of several virulence genes. It...
Open access
Research Article10.9734/jpri/2021/v33i48B33290
Introduction: Opuntia ficus-indica is a well adapted cactus to extreme climatic environments. In the usual diet and food industry, it is an interesting source of food ingredients. In general, the protective role of prickly pears has been due to their antioxidant components, pheno...
Open access
Research Article10.9734/jpri/2021/v33i47B33148
Background: Acinetobacter baumannii is a gram negative non-motile coccobacillus, which was considered as a low priority pathogen with low virulence. Recently, it was declared as the priority pathogen under the critical category of the most dangerous pathogen by WHO. Acinetobacter...
Open access
Research Article10.9734/jpri/2021/v33i47B33156
Background: Plants, herbs and plant derived compounds have been used since decades in folk and traditional medicine. These compounds were found to be non-toxic and compatible with the human cells. Screening of this exhaustive collection of compounds seems to be a herculean task....
Open access
Research Article10.9734/jpri/2021/v33i64B35738
Introduction: Genetic alterations have long been associated with the transformation of normal cells into malignant cells. Several genes are related to exhibiting the phenotype. The PARP gene family is mainly involved in maintaining genome stability. They play an important role in...
Open access
Research Article10.9734/jpri/2021/v33i64A35692
Background: Head and neck squamous cell carcinoma is considered to be a common type of human cancer. It is highly invasive with limited therapeutic options outside surgery, chemotherapy and radiation. Cadherin family genes comprises a family with more than 110 members which are...
Open access
Research Article10.9734/jpri/2021/v33i63B35668
Introduction: Antimicrobial peptides (AMPs) are small molecules which are known to exert destructive effects upon pathogenic microorganisms. AMPs are designed from proteins obtained from various sources and tested under in vitro conditions to deduce their antimicrobial activity....
Open access
Research Article10.9734/jpri/2021/v33i58A34094
Introduction: Hypericin is the anthraquinone derivative and has many properties like antiviral, antifungal and antibacterial. The red complex pathogens which include Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia in association with other microbes found i...
Open access
Research Article10.9734/jpri/2021/v33i48B33292
Introduction: Periodontal disease is an infection of the tissues that hold your teeth in place. It's typically caused by poor brushing and flossing habits that allow plaque, a sticky film of bacteria, to build up on the teeth and harden. Elimination of these pathogens from the si...
Open access
Research Article10.9734/jpri/2021/v33i47B33166
Introduction: Triclosan is considered to be an important ingredient in toothpastes and mouth rinses. Several studies have reported contradictory results regarding the antimicrobial effect of triclosan. Hence, the present in silico study intends to identify the potential targets o...
Open access
Research Article10.9734/jpri/2021/v33i47B33169
Introduction: HNSCC is a type of cancer in the oral and pharynx region. Several mutations/variations are observed in these cancer phenotypes. Fibroblast growth factor belongs to the family of heparin binding growth factors. FGFs are multifunctional proteins with a wide variety of...
Open access
Research Article10.9734/jpri/2021/v33i47B33172
Introduction: Head and neck squamous cell carcinoma (HNSCC) is an aggressive life-threatening disease associated with high mortality rates. Several genes related to stress response have been studied extensively to reveal their possible association with HNSCC. Members of the HSPA...
Open access
Research Article10.9734/jpri/2021/v33i47B33136
Background: Antimicrobial drug resistance is the major problem encountered world-wide. Novel therapeutic leads have been identified and are regularly tested for their activity against microbial pathogens. Aim: To identify the protein network interactions of triclosan in red compl...
Open access
Research Article10.9734/jpri/2021/v33i47B33137