Skip to content
S

Selvaraj Jayaraman

Publications (32)

Induction of Bax and Activation of Caspases Hydro Ethanoic Leaf Extract of Citrullus colocynthis(L)- Mediated Apoptosis in Human Liver Cancer Cells Hep G2

K. Swetha, A. Jothi Priya, Selvaraj Jayaraman & R. Gayatri Devi · Journal of Pharmaceutical Research International · 2022

Introduction: Citrullus colocynthis is a desert plant of the cucurbitaceae family. C. colocynthis grows in many countries with semi dry lands and that seeds are rich in oil which can encourage their sustainable agriculture to produce an economic biodiesel with a competitive price...

Open access Research Article 10.9734/jpri/2022/v34i27B36001

Tooth Mobility Pattern in Periodontitis Patients with Diabetes Mellitus

Aarthi Muthukumar, M. Jeevitha, Selvaraj Jayaraman & M. Naveen Kumar · Journal of Pharmaceutical Research International · 2021

Background: Tooth mobility may be a common problem among patients seeking dental treatment. Tooth mobility is defined as an extent of horizontal and vertical tooth displacement created by external forces, trauma and periodontal diseases. Aim: The aim of the present study is to ev...

Open access Research Article 10.9734/jpri/2021/v33i64B35326

Measurement of Salivary Tumor Necrosis Factor- alpha (TNF- α) in Periodontitis Patients with or without Diabetes Mellitus

A. Swetaa, M. Jeevitha & Selvaraj Jayaraman · Journal of Pharmaceutical Research International · 2021

Introduction: Tumor necrosis factor-alpha (TNF-α) is a proinflammatory mediator considered to be a soluble mediator released from immunocompetent cells. It exercises a wide range of proinflammatory and immunomodulatory effects in different cell populations, such as stimulating pr...

Open access Research Article 10.9734/jpri/2021/v33i62B35163

Assessment of 8-Hydroxy 2-Deoxyguanosine as Salivary Biomarker for Periodontitis Patients with or without Diabetes Mellitus

M. Ashwin Shravan Kumar, M. Jeevitha & Selvaraj Jayaraman · Journal of Pharmaceutical Research International · 2021

Aim: The aim of this study is to assess the levels of 8-hydroxy-2 deoxyguanosine as a salivary biomarker for periodontitis with or without diabetes mellitus. Study Design: Cross-sectional study Materials and Methods: 30 patients were included in the study and were categorised int...

Open access Research Article 10.9734/jpri/2021/v33i62B35164

Quantitative Analysis of Tannerella Forsythia Level in Periodontitis Patients with or without Diabetes Mellitus

A. Baalavignesh, M. Jeevitha & Selvaraj Jayaraman · Journal of Pharmaceutical Research International · 2021

Introduction: Periodontitis is a systemic chronic inflammatory disease resulting from a complex polymicrobial infection causing tissue destruction as a consequence of perturbation of the homeostasis between sub gingival microflora. T.forsythia has been strongly implicated in the...

Open access Research Article 10.9734/jpri/2021/v33i62B35166

Induction of Bax and Activation of Caspases by Hydro Ethanolic Leaf Extract of Citrullus colocynthis (L)-mediated Apoptosis in Breast Cancer Cell Line (MCF-7)

R. Bharath, A. Jothi Priya, Selvaraj Jayaraman & R. Gayatri Devi · Journal of Pharmaceutical Research International · 2021

Cancer is the most deadly disease that causes death among the world. It is caused by genome and epigenome abnormalities. Herbal plants are used for treatment of cancer. Citrullus colocynthis is valuable medicinal plants used for treatment of cancer. The plant as antidiabetic, ant...

Open access Research Article 10.9734/jpri/2021/v33i62B35184

Prevalence of the Use of Particulate Graft versus Block Bone Graft in Ridge Augmentation: A Hospital Based Retrospective Study

S. Tasleem Abitha, M. Jeevitha, Selvaraj Jayaraman & M. Naveen Kumar · Journal of Pharmaceutical Research International · 2021

Aim: To assess the prevalence of the use of particulate graft versus block bone graft in ridge augmentation. Introduction: Ridge augmentation is a process of replacing the lost bone of residual ridge by grafting natural or synthetic material. Dimensional changes in the alveolar r...

Open access Research Article 10.9734/jpri/2021/v33i63B35284

Comparative Evaluation of Salivary Interleukin-18 in Periodontitis Patients with or without Diabetes Mellitus

B. Chithralekha, M. Jeevitha & Selvaraj Jayaraman · Journal of Pharmaceutical Research International · 2021

Aim: The study was conducted to compare the salivary concentrations of interleukin-18 in periodontitis patients with or without diabetes mellitus Materials and Methods: The sample size in the study was 30 and categorized into 3 groups, in each group 10 individuals were included i...

Open access Research Article 10.9734/jpri/2021/v33i62A35162

Activity of Hydroethanolic Leaf Extract of Tecoma stans against Breast Cancer Cells Line - MCF - 7

Chevuru Sai Shreya Reddy, Lavanya Prathap, Selvaraj Jayaraman & S. Preetha · Journal of Pharmaceutical Research International · 2021

Background: Cancer is abnormal growth of cells, which invade or spread to other parts of the body. There are over 200 types of cancers. Breast cancer is a cancer which develops in tissues of the breast, most commonly originating from the inner lining of milk ducts or lobules that...

Open access Research Article 10.9734/jpri/2021/v33i62A35193

A Comparative Evaluation of the Measurement of Interleukin-1β as Salivary Biomarker in Periodontitis Patients with and without Diabetes Mellitus

A. Divya Dharshini, M. Jeevitha & Selvaraj Jayaraman · Journal of Pharmaceutical Research International · 2021

Introduction: Periodontitis is characterized by inflammatory destruction of connective tissue, loss of periodontal attachment, and resorption of the alveolar bone. Because of its activity as an inflammatory mediator as well as a modulator of the extracellular matrix and bone, the...

Open access Research Article 10.9734/jpri/2021/v33i61B35528

Role of Endogenous Serotonin Replica Mediated Through β-Catenin/Wnt Signaling in Lung Cancer Prevention and Prognosis - an in-vitro Study in A549 Cancer Cell Lines

M. Rishikesan, Lavanya Prathap, Selvaraj Jayaraman & S. Preetha · Journal of Pharmaceutical Research International · 2021

Background: Lung cancer is still the most common cause of carcinoma-related death in the globe. Non-pharmacological treatments such as physical activity and exercise have been shown to improve quality of life and provide better results in lung cancer patients. Lung cancer patient...

Open access Research Article 10.9734/jpri/2021/v33i60B35052

Tooth Loss Patterns in Patients with Periodontitis and Diabetes Mellitus

T. Cibikkarthik, M. Jeevitha & Selvaraj Jayaraman · Journal of Pharmaceutical Research International · 2021

Aim: Periodontitis is an inflammatory, multifactorial disease which results in destruction of supporting tissue and bone thereby resulting in loosening of the tooth. Tooth loss is one of the major oral issues faced by elderly patients. Thus the present study aimed to investigate...

Open access Research Article 10.9734/jpri/2021/v33i60B35083

Tooth Loss Patterns in Hypertensive Patients with Chronic Periodontitis

Vigneshwaran Ravichandran, M. Jeevitha & Selvaraj Jayaraman · Journal of Pharmaceutical Research International · 2021

Aim: The aim of the study is to study the tooth loss pattern in patients with chronic periodontitis and hypertension. Study Design: Retrospective cohort study. Materials and Methods: The case sheet records (DIAS data) of tooth loss pattern in hypertensive patients with chronic pe...

Open access Research Article 10.9734/jpri/2021/v33i60B35087

Knowledge, Awareness and Practice of Periodontal Therapy during Pregnancy among Dental Professionals

P. Santhanam, M. Jeevitha, Selvaraj Jayaraman & M. Naveen Kumar · Journal of Pharmaceutical Research International · 2021

Aim: To assess the knowledge, awareness and practice of periodontal therapy during pregnancy among dental professionals Materials and Methods: This cross-sectional study was conducted among 100 dental professionals in and around Chennai. A well-structured questionnaire consisted...

Open access Research Article 10.9734/jpri/2021/v33i60B35100

Comparative Assessment of P. gingivalis Level in Periodontit is Patients with and without Diabetes Mellitus- A PCR based Study

M. Shruthi, M. Jeevitha, N. D. Jayakumar & Selvaraj Jayaraman · Journal of Pharmaceutical Research International · 2021

Introduction: Periodontal diseases if left untreated can lead to tooth loss with the main cause being bacterial plaque. Among the subgingival plaque bacterial species, Porphyromonasgingivalis has been implicated as a major etiological agent causing tooth loss. Diabetic patients a...

Open access Research Article 10.9734/jpri/2021/v33i64A35308

Measurement of Salivary Lipid Peroxidation in Periodontitis Patients with or Without Diabetes Mellitus

V. P. R. B. Ranjith Raj, M. Jeevitha, N. D. Jayakumar & Selvaraj Jayaraman · Journal of Pharmaceutical Research International · 2021

Aim: The aim of the present study is to assess the association of lipid peroxidation in the saliva of healthy and periodontitis patients with or without diabetes mellitus. Study Design: Cross-sectional study. Materials and Methods: The study was conducted in the subjects who visi...

Open access Research Article 10.9734/jpri/2021/v33i64A35320

Quantification of Caspase 3 Levels in Patients with Periodontitis with or without Diabetes Mellitus

S. M. Azima Hanin, M. Jeevitha, N. D. Jayakumar & Selvaraj Jayaraman · Journal of Pharmaceutical Research International · 2021

Background: Diabetes mellitus is a debilitating systemic disease with several major complications affecting the quality and length of life. Periodontal disease has been considered another diabetic complication in addition to cardiovascular disease, nephropathy, neuropathy, periph...

Open access Research Article 10.9734/jpri/2021/v33i62B35173

Abies webbiana Mediated Zinc Oxide Nanoparticles and Its Anti-inflammatory Activity

S. Priyadharshini, M. Jeevitha, S. Rajeshkumar & Selvaraj Jayaraman · Journal of Pharmaceutical Research International · 2021

Introduction: Green nanoparticle synthesis provides a number of advantages, including being environmentally friendly, taking less time, being less expensive, being more stable, and, most significantly, not requiring the use of harmful chemicals. Aim: The aim of the present study...

Open access Research Article 10.9734/jpri/2021/v33i62B35174

Green Synthesis and Antioxidant Activity of Silver Nanoparticles Synthesized Using Ficus benghalensis

Amit Kumar Singh, M. Jeevitha, S. Rajeshkumar & Selvaraj Jayaraman · Journal of Pharmaceutical Research International · 2021

Background: Nanoparticles are materials with overall dimensions in the nanoscale, ie, under 100 nm. Silver nanoparticles (AgNPs) have shown excellent bactericidal properties against a wide range of microorganisms. Ficus benghalensis is a very large tree and had been considered as...

Open access Research Article 10.9734/jpri/2021/v33i62B35177

Antioxidant Activity of Abies webbiana Mediated Zinc Oxide Nanoparticles

T. Vinaya Swetha, M. Jeevitha, S. Rajeshkumar & Selvaraj Jayaraman · Journal of Pharmaceutical Research International · 2021

Background: Biological methods for nanoparticle (NP) synthesis using microorganisms, enzymes, and plants or plant extracts have been suggested as possible eco-friendly alternatives to chemical and physical methods. Aim: The aim of the current study is to synthesize Zinc oxide nan...

Open access Research Article 10.9734/jpri/2021/v33i62B35179

Virtual Screening to Identify Protein Targets of Aggregatibacter Actinomycetemcomitans Interacting with Emodin

R. Preety, M. Jeevitha, J. Vijayashree Priyadharsini & Selvaraj Jayaraman · Journal of Pharmaceutical Research International · 2021

Aim: The aim of the study is to identify protein targets of aggregatibacter actinomycetemcomitans interacting with emodin. Introduction: Aggregatibacter mycetemcomitans is a gram negative bacteria that is associated with localized chronic periodontitis and other systemic diseases...

Open access Research Article 10.9734/jpri/2021/v33i62B35579

Transforming Growth Factor Beta as Salivary Biomarker in Periodontitis Patients with or without Diabetes Mellitus

B. Revathi, M. Jeevitha, N. D. Jayakumar & Selvaraj Jayaraman · Journal of Pharmaceutical Research International · 2021

Aim: To estimate the salivary TGF-beta levels in periodontitis patients with or without diabetes mellitus Materials and methods: Thirty patients [15 males and 15 females] were included in this study and divided into three groups. Group a included 10 participants with periodontal...

Open access Research Article 10.9734/jpri/2021/v33i63B35290

Preparation of Mouthwash using Ficus benghalensis Assisted Silver Nanoparticles and a Comparative Analysis of Its Antimicrobial Activity

M. Rangeela, M. Jeevitha, S. Rajeshkumar & Selvaraj Jayaraman · Journal of Pharmaceutical Research International · 2021

Aim: The aim of this study is to prepare a mouthwash using Ficus benghalensis mediated silver nanoparticles (Ag NPs) and analysing its antimicrobial activity against oral pathogens Introduction: Nanotechnology deals with the particles which are less than 100 nm and have important...

Open access Research Article 10.9734/jpri/2021/v33i60B35061

Antimicrobial Activity of Zinc Oxide Nanoparticles Synthesized Using Leaves Extract of Abies webbiana

R. Nivethitha, M. Jeevitha, S. Rajeshkumar & Selvaraj Jayaraman · Journal of Pharmaceutical Research International · 2021

Introduction: Green synthesis of nanoparticles using plant extract, bacteria, fungi and enzymes are eco-friendly and cost effective which do need high pressure, energy, temperature and toxic chemicals for its synthesis protocol. Zinc oxide nanoparticles have various physical, che...

Open access Research Article 10.9734/jpri/2021/v33i60B35065

Cytotoxic Activity of Zinc Oxide Nanoparticle Synthesis Using Leaves Extract of Abies webbiana

M. Srinisha, M. Jeevitha, S. Rajeshkumar & Selvaraj Jayaraman · Journal of Pharmaceutical Research International · 2021

Aim: The present study aimed to analyse the cytotoxicity of zinc oxide nanoparticles (ZnO NPs) that are biosynthesized using extract of Abies webbiana Methodology: Zinc oxide nanoparticles were synthesized by green approach using A. webbiana and were characterized by UV- vis spec...

Open access Research Article 10.9734/jpri/2021/v33i60B35067

Cytotoxic Activity of Silver Nanoparticles Synthesized using F. benghalensis

Abigail Ranasinghe, M. Jeevitha, S. Rajeshkumar & Selvaraj Jayaraman · Journal of Pharmaceutical Research International · 2021

Aim: To determine the cytotoxic activity of silver nanoparticles synthesized using Ficus benghalensis. Introduction: Synthesis of metal nanoparticles is widely used due to their potential applicability in various areas such as electronics, chemistry, energy and medicine developme...

Open access Research Article 10.9734/jpri/2021/v33i60B35071

Knowledge, Awareness and Practice of Usage of Interdental Aids among Dental Professionals

Lasya Genji, M. Jeevitha, S. Preetha & Selvaraj Jayaraman · Journal of Pharmaceutical Research International · 2021

Aim: To evaluate knowledge, awareness and practice of usage of interdental aids among dental professionals. Introduction: Dental caries and periodontal diseases, the two most common oral diseases, are mainly avoidable by professional and self-care activities. Dentists’ knowledge...

Open access Research Article 10.9734/jpri/2021/v33i60B34721

Controlling Oral Pathogens using Ficus Benghalensis Mediated Silver Nanoparticles

K. Thirumagal, M. Jeevitha, S. Rajeshkumar & Selvaraj Jayaraman · Journal of Pharmaceutical Research International · 2021

Aim: To find antimicrobial property of Ficus benghalensis mediated silver nanoparticles (AgNPs) Introduction: Nanoparticles have been studied in recent years because of certain properties like physical, chemical, electronic, thermal, magnetic, optical, dielectric and biological....

Open access Research Article 10.9734/jpri/2021/v33i60B34591

Correlation of Streptococcus Mutans by 16SrRNA Gene Sequencing in Children with Different Caries Experience- A PCR Based Study

Dhanalakshmi Ravikumar, Pratibha Ramani, R. Gayathri & Selvaraj Jayaraman · Journal of Pharmaceutical Research International · 2021

Background and Objectives: Early Childhood Caries is considered as a common chronic disease in children. Since some research had concluded that children with higher levels of Streptococcus mutans are associated with a higher incidence of decayed, missing, and filled teeth, the pr...

Open access Research Article 10.9734/jpri/2021/v33i41B32341

A Review on Impact of Glyphosate on Development of Cancer

Monisha Prasad, U. Vidhya Rekha, Ponnulakshmi Rajagopal, Durairaj Sekar & Selvaraj Jayaraman · Journal of Pharmaceutical Research International · 2021

Pesticides are a vast mixture of compounds used to control pests like plants, moulds, and insects. In agriculture, non-agricultural vegetation management, and crop desiccant harvesting aid, chemicals from every major functional family of pesticides, such as insecticides, herbicid...

Open access Research Article 10.9734/jpri/2021/v33i62A35551

Antidiabetic Activity of Clitoria ternatea Linn

K. Kalaiselvi, U. Vidhya Rekha, Ponnulakshmi Rajagopal, Durairaj Sekar & Selvaraj Jayaraman · Journal of Pharmaceutical Research International · 2021

In recent years, interest in plant study has expanded all over the world and a substantial body of evidence has been collected to illustrate the great potential of medicinal plants utilized in diverse traditional systems. Plant-based medications and chemicals have been used to tr...

Open access Research Article 10.9734/jpri/2021/v33i61B35537

Review on Chitosan Intake and Enhancement in Fecal Excretion of Endocrine Disruptors

Bhuvaneswari Ponnusamy, U. Vidhya Rekha, Ponnulakshmi Rajagopal, Durairaj Sekar & Selvaraj Jayaraman · Journal of Pharmaceutical Research International · 2021

Chitin is most abundantly found non-digestible carbohydrate similar to cellulose. It has gained a lot of interest in last few years due to its wide range of applications. They are used as an alternative, dietary supplement. Chitin on deacetylation forms chitosan, an active compon...

Open access Research Article 10.9734/jpri/2021/v33i61B35536