Influence of Alpha-thalassemia −3.7kb Mutation (αα/-α and -α/-α) upon Clinical Outcome of Homozygous Sickle Cell Disease
Siris Patel, Praveen K. Sahu & Preetinanda M. Dash · Asian Hematology Research Journal · 2022
Alpha thalassemia (α-thal), fetal haemoglobin (HbF) and beta-globin haplotype are considered classical genetic disease modifiers in Sickle cell disease (SCD) causing clinical heterogeneity. Nevertheless their impact on clinical emergence and disease progression is still elusive....