Snehasis Maiti

Computer-Aided Drug Design Approaches for Benzilic Acid and Benzilate Derivatives: From Muscarinic Antagonists to Scaffold-Centred Workflows

Sipra Sarkar Banerjee, Sougata Kumar Mondal & Snehasis Maiti · Journal of Pharmaceutical Research International · 2026

Benzilic acid (2-hydroxy-2,2-diphenylacetic acid) and its derivatives occupy a distinctive niche in medicinal chemistry because the scaffold naturally combines (i) a bulky, “aryl-rich” hydrophobic domain and (ii) a polar, acid/ester-bearing handle that can be tuned for permeabili...