Background: Anti-CD20 monoclonal antibodies, including rituximab (RTX) and ocrelizumab (OCR), have markedly improved the management of multiple sclerosis (MS) by reducing inflammatory disease activity. However, local evidence regarding their effectiveness and safety in real-world...
Open access
Research Article10.9734/ajorrin/2026/v9i1187
This study investigated the effect of cadmium exposure and Annona muricata (soursop) leaf extract on the cortical histology of adult albino rats. Cadmium is a recognised environmental toxicant capable of inducing neurodegeneration through oxidative stress and inflammatory pathway...
Open access
Research Article10.9734/ajorrin/2026/v9i1188
Climate change is altering the environmental cycling of a diverse range of contaminants, with consequences for their bioaccumulation in food webs and their neurotoxic potential in wildlife and humans. Rising temperatures, permafrost and glacial thaw, wildfire activity, sea level...
Open access
Research Article10.9734/ajorrin/2026/v9i1186
Aims: The use of medicinal plants in sub-Saharan Africa raises concerns regarding neurological safety. This study evaluated the effects of sub-chronic oral administration of ethanolic leaf extracts of Rauwolfia vomitoria (RV) and Gongronema latifolium (GL), singly and in combinat...
Open access
Research Article10.9734/ajorrin/2026/v9i1185
Cannabis remains the most widely used controlled substance worldwide, and its relationship with common and severe mental disorders continues to generate scientific and public health debate. This narrative review synthesises evidence published across pharmacological, epidemiologic...
Open access
Research Article10.9734/ajorrin/2026/v9i1184
Scrub typhus is an endemic zoonotic infection within the Tsutsugamushi Triangle and is an important cause of acute febrile illness with variable systemic and neurological manifestations. Guillain-Barré syndrome (GBS) is an uncommon peripheral nervous system complication, and bila...
Open access
Research Article10.9734/ajorrin/2026/v9i1183
Creutzfeldt-Jakob disease is a rare, rapidly progressive prion disorder that most commonly presents with cognitive decline, myoclonus, cerebellar signs, and other neuropsychiatric manifestations. Atypical presentations may delay recognition, particularly when the initial clinical...
Open access
Research Article10.9734/ajorrin/2026/v9i1182
Toyin Tolulope Lawal, Naomi Ama Kedador, Funmilade Taiwo Adetola, Reuben Adelala Aragbaye, Olachi Emenyonu, Chinyere Abigail Onyekwum & Fausta Chinyere Diala-Obi·Asian Journal of Research and Reports in Neurology·2026
Neurodegenerative disorders are associated with progressive neuronal dysfunction, synaptic loss, and cognitive decline. Increasing evidence indicates that chronic neuroinflammation contributes to these processes through sustained interactions between immune and neural pathways. T...
Open access
Research Article10.9734/ajorrin/2026/v9i1181
Caffeine is a non-selective antagonist of adenosine A1 and A2A receptors, whereas Vernonia amygdalina contains phytochemicals with reported antioxidant and anti-inflammatory properties. Although both agents have been examined separately, information on their comparative and combi...
Open access
Research Article10.9734/ajorrin/2026/v9i1180
The prefrontal cortex is a major region of the brain involved in cognition, emotional regulation, decision-making, and behavioral coordination, and is highly susceptible to neurochemical alterations induced by central nervous system depressants. This study investigated the histom...
Open access
Research Article10.9734/ajorrin/2026/v9i1179