Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and memory loss, significantly impacting millions worldwide. The accumulation of amyloid-β (Aβ) plaques in the brain is a central feature of AD pathology, making it a key targe...
Open access
Research Article10.9734/indj/2025/v22i3480
Alzheimer's disease (AD), a progressive and unrelenting memory loss, gradually weakens cognitive and independent functioning. There is currently no cure despite decades of research, and existing medicines simply alleviate symptoms. A complex interaction between hereditary variabl...
Open access
Research Article10.9734/indj/2025/v22i3479
Eru, E.M, Theresa I. Ekpenyong, Cyril A. Agbor, Christie E. Fischer, Michael E. Oku, Samson O. Paulinus, Etim D. Isaiah, Kelechi C. Uruakpa, Williams A. Nnenna, Nsikak M. Umoh, Eric A. Agaba & Anozeng O. Igiri·International Neuropsychiatric Disease Journal·2025
Aim: the aim of this study was to elucidate the effect of alkaloid-rich fraction of Dacryodes edulis on body weight, blood glucose level and the microanatomy of the hippocampus of STZ-induced Diabetic Wistar rats. Methodology: 25 adult male Wistar rats were used for the experimen...
Open access
Research Article10.9734/indj/2025/v22i3477
Background: Carbon soot particulate matter (PM2.5) from crude oil combustion poses significant health risks; however, its systemic and neurological effects remain understudied. This study investigated the impact of chronic carbon soot PM2.5 inhalation on body weight and cerebella...
Open access
Research Article10.9734/indj/2025/v22i3478
Alzheimer's disease is a progressive neurological disorder that primarily affects older adults and is the most common cause of dementia. It involves the degeneration of brain cells, leading to memory loss, cognitive decline, and changes in behavior and personality. Worldwide, an...
Open access
Research Article10.9734/indj/2025/v22i3476
Williams Afamuefuna Nnenna, Ifiok Francis Bassey, Eru Mba Eru, Cyril Abang Agbor, Wilson Okwudili Nnenna, Theresa Ekpenyong Isamoh, Nsikak Michael Umoh, Charles Effiong Asukwo, Emmanuel Izuchukwu Odom & Anozeng Oyono Igiri·International Neuropsychiatric Disease Journal·2025
Introduction: Epilepsy is a chronic neurological disorder characterized by recurrent seizures that severely impact quality of life. The increasing need for safer and more effective anticonvulsant therapies has led to the exploration of herbal remedies. This study investigates the...
Open access
Research Article10.9734/indj/2025/v22i2475
Tramadol hydrochloride (TRM) is widely used for pain management, but chronic exposure can lead to neurotoxicity. Sinapic acid (SA) has been reported to be a potent antioxidant. This study investigates the impacts of SA against TRM-induced oxidative and morphological damage in the...
Open access
Research Article10.9734/indj/2025/v22i2474
Gastrodia elata commonly called Tianmab is a traditional medicinal herb widely used in East Asia for its purported neuroprotective effects. This mini-review summarizes the current understanding of the bioactive compounds within G. elata and their potential mechanisms of action re...
Open access
Research Article10.9734/indj/2025/v22i2473
Background: Industrial effluents contain hazardous contaminants that pose significant risks to environmental and public health, including neurotoxicity. This study aimed to evaluate the histopathological effects of treated and untreated industrial effluents from Notore Chemicals...
Open access
Research Article10.9734/indj/2025/v22i2472
The surge in the prevalence of neurodevelopmental conditions including Autism Spectrum Disorder; a Disarray typically defined by a wide variety of conditions marked by difficulties in social skills, repetitive behaviors, disorganized speech, and challenges with nonverbal communic...
Open access
Research Article10.9734/indj/2025/v22i2471