The objective of this study is to present convincing evidence to show that abnormal methylation enzymes (MEs) are the most critical issue of cancer, and to call for the acceptance of cell differentiation agent (CDA) formulations as the right medicines for cancer therapy. CDA form...
Neurofibromatosis type 1 (NF1) is a genetic disorder characterized by the growth of both benign and malignant tumors in neural crest cells. Despite extensive research, only one medication has been approved for plexiform neurofibroma treatment, and no specific drugs exist for othe...
A crucial stage in the development of cancer is metastasis, which greatly increases patient morbidity and mortality. The process of metastasis involves several steps, starting with the local invasion of cancer cells into the surrounding tissues, then extravasation, colonization a...
Lung-only metastasis in Ewing Sarcoma (ES) is a rare presentation in an otherwise common skeletal malignancy with a poor 5-year overall survival (OS) of 30% and a 10-year event-free survival (EFS) of 50.3%, respectively. We report a first case of a 11-year-old male with ES lung-o...
Okelue Edwards Okobi, Sebastian A. Omenai, Tolulope Yemisi Ogunyemi, Lateef Kadiku, Chinwendu Olivia, Ayozie- Chukukere, Omoniyi Araromi, Ifeoma Anaya, Ibilola Akorede Sanusi, Omolola Okunromade, Endurance Evbayekha, Emeka Kenneth Okobi, Jane Nwafor & Abiodun Oladimeji·International Research Journal of Oncology·2023
Tissue staining techniques have been an integral part of pathology for over a century. These techniques allow pathologists to visualize the structure and composition of tissues under a microscope. These techniques play a crucial role in the diagnosis and treatment of a wide range...
The phenomenon of dormancy in cancer and tumor cells is defined by the halting of cell division and the preservation of a dormant or slow-growing condition. Cells can stay in this state long after the underlying tumor has been excised or after surveillance and therapeutic interve...
Breast cancer is the most common cancer diagnosed in females throughout the entire world, and it is also the primary reason why people lose their lives due to malignant tumors. The risk of developing breast cancer is increasing at an alarming rate over the whole planet. In light...
Wound healing requires the proliferation and the terminal differentiation of PSCs, the most primitive stem cells expressing abnormal differentiation enzymes (MEs). Wound if not healed properly, PSCs may be forced to evolve into cancer stem cells (CSCs), and then to progress to fa...
Introduction: Cardiac involvement during Hodgkin lymphoma is rare and is often seen at a late stage of the disease. The diagnosis of cardiac localization is difficult to make while the patient is alive, Transthoracic echocardiography is used to identify cardiac involvement in mos...
Malignant Melanoma of the eyelid skin arises from the abnormal proliferation of melanocytes. It is a rare condition that accounts for < 1% of all melanomas. They are usually a result of DNA damage from exposure to UVB (290-320). Other common risk factors include Fair skin, red...