Concentration measurements of drugs and their metabolites in biological matrices underpin regulatory decisions on safety, efficacy and labelling, and the technical requirements governing those measurements were, for three decades, set regionally. Guideline M10 of the Internationa...
Open access
Research Article10.9734/jamps/2026/v28i8882
Epilepsy is a chronic non-communicable brain disease affecting approximately 50 million people of all ages worldwide. Antiepileptic drugs (AEDs) are used to manage epileptic seizures. However, AEDs may fail to control seizure activity in some patients and may cause unwanted effec...
Open access
Research Article10.9734/jamps/2026/v28i8881
Background: Male infertility remains a significant reproductive health challenge. Seminal plasma biochemical markers, including fructose, zinc, and citric acid, play essential roles in sperm metabolism, motility, and overall reproductive function. Their evaluation alongside sperm...
Open access
Research Article10.9734/jamps/2026/v28i8880
Background: Hypertension is highly prevalent among Black adults and contributes substantially to stroke, heart failure, kidney disease, and premature cardiovascular morbidity. Thiazide and thiazide-like diuretics are widely recommended as foundational antihypertensive agents, but...
Open access
Research Article10.9734/jamps/2026/v28i8877
Limb-girdle muscular dystrophy type 2I, now designated R9 (LGMD2I/R9), is an autosomal recessive dystroglycanopathy caused by biallelic pathogenic variants in the fukutin-related protein (FKRP) gene. Loss of FKRP glycosyltransferase activity disrupts the ribitol-phosphate-mediate...
Open access
Research Article10.9734/jamps/2026/v28i8878
Sara S. Abdelrahim, Mohammed H. Alnazeer, Mawahib A. Mustafa, Safa A. Abdalla, Elkhanssa Abdelhameed Ahmed Elhag, Kannan O. Ahmed, Yasir S. Kheir, Elmoiz Babekir & Bashir A. Yousef·Journal of Advances in Medical and Pharmaceutical Sciences·2026
Background: Imatinib mesylate is a tyrosine kinase inhibitor that has transformed the treatment of chronic myeloid leukaemia. However, information on its real-world use among sub-Saharan African populations remains limited. Aims: This study evaluated early haematological response...
Open access
Research Article10.9734/jamps/2026/v28i8879
Background: Malaria mortality studies in Ghana and sub-Saharan Africa have commonly relied on traditional regression approaches or generalised additive models, which may not fully represent delayed transmission effects, nonlinear exposure-response patterns, or uncertainty in mort...
Open access
Research Article10.9734/jamps/2026/v28i7876
Vitamin D is important for calcium homeostasis and skeletal health, while obesity may influence circulating vitamin D concentrations through altered metabolism and adipose tissue sequestration. This study assessed vitamin D status and selected biochemical markers related to bone...
Open access
Research Article10.9734/jamps/2026/v28i7875
Stage IV non-small cell lung cancer (NSCLC) has long been treated as a domain for systemic therapy and palliation alone, with surgery reserved for managing complications rather than for controlling disease. That position has shifted markedly over the past decade. It is now recogn...
Open access
Research Article10.9734/jamps/2026/v28i7874
Background: The Niger Delta region of Nigeria hosts one of the largest crude oil reserves in Africa. Decades of oil exploration and production have released a wide range of toxic heavy metals into the environment. While lead (Pb), cadmium (Cd), and nickel (Ni) have attracted cons...
Open access
Research Article10.9734/jamps/2026/v28i7872