Quantitative structure-activity relationship (QSAR) models were combined with density functional computations and used to predict anti-fungi activities in a series of coumarin derivatives. Essential descriptors employed in this study were chosen based on the use of the Genetic Fu...
Open access
Research Article10.9734/JAMPS/2018/22801
Aim: The aim of this study was to implement an in silico bioinformatics analysis for clinically observed missense variants in human DPYD gene to investigate the effect these variants on Dihydropyrimidine dehydrogenase enzyme 's structure and function. Methods: The human DPYD gene...
Open access
Research Article10.9734/JAMPS/2018/40300
Aim: This study was carried out to investigate the effect of captopril on serum liver enzymes (AST, ALT, and ALP), total serum protein and kidney function parameters such as electrolytes (HCO3-, Cl-, Na+, and K+), urea and creatinine in Plasmodium berghei-infected mice. Methodol...
Open access
Research Article10.9734/JAMPS/2018/40599
Background: The increase in consumption of industrial processed food, economic instability consequent to global economic recession; job losses; increase incidence of diabetes and chronic kidney disease; increase steroids use; dyslipidemia; and obesity has been implicated in the g...
Open access
Research Article10.9734/JAMPS/2018/40194
Aims: To determine the influence of Aegopodium podagraria L. aerial part extract on the function of the kidney and the metabolic processes in rats receiving hydrochlorothiazide (HCTZ, 80 mg/kg). Study Design: The rats were randomly distributed to five groups: Group I: int...
Open access
Research Article10.9734/JAMPS/2018/40313
Aims: To determine the phytochemical constituents and antibacterial potential of Cynodon dactylon leaf extracts against Escherichia coli. Study Design: Experimental short-term prospective study. Place and Duration of Study: The study was conducted in Kampala International Univers...
Open access
Research Article10.9734/JAMPS/2018/39990
Aims: The aim of this study was to find out the cytotoxicity and antibacterial activity of the methanolic extract of leaf of Antidesma bunius (Family Euphorbiaceae). Place and Duration of Study: The study was carried out in August 2017 in the Department of Pharmacy, Southeast Uni...
Open access
Research Article10.9734/JAMPS/2018/40004
Background: Malaria is a major cause of morbidity and mortality in Nigeria accounting for a significant proportion of household expenditure in treatment and prophylaxis. Nigeria account for 25% of global clinical cases and mortality and also has the highest malaria burden in su...
Open access
Research Article10.9734/JAMPS/2018/31413
Aims: Malaria parasites are expected to impact the white blood cell differential of malaria patients, but reports on changes in white blood cell differentials of malaria patients are not well documented, hence this study was undertaken to determine changes in white blood cell dif...
Open access
Research Article10.9734/JAMPS/2018/38784
Introduction: Blockade of renin-angiotensin-aldosterone system (RAAS) has been shown to be beneficial in patients with hypertension, acute myocardial infarction, chronic heart failure and diabetic renal disease. However, RAAS inhibitors and diuretic therapy are associated with so...
Open access
Research Article10.9734/JAMPS/2018/39209