Neuroblastoma is the most common solid abdominal tumor in children under the age of 2 years and accounts for approximately 15% of childhood mortality due to cancer. Its clinical behavior can vary from spontaneous regression to rapid fatal progression and anywhere in between (e.g....
Open access
Research Article10.9734/JCTI/2015/16165
Erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis are rare and severe cutaneous syndrome that are usually drug related. Aromatic oral anticonvulsants (e.g.: phenobarbital, phenytoin, carbamazepine) are recognized as the most common cause of these disord...
Open access
Research Article10.9734/JCTI/2015/18387
Triple-negative breast cancer is a type of aggressive breast cancer without the immunohistochemical expression of estrogen receptors, progesterone receptors and human epidermal growth factor receptor-2; with poor prognosis, greater relapse risk and worse survival in general. Its...
Open access
Research Article10.9734/JCTI/2015/18131
Pulmonary metastasis rarely originates from a benign tumour, but may occur from giant-cell tumours of bone (GCT). It occurs most frequently in recurrent cases and may result in poor outcomes. We report a case with pulmonary metastases from huge ulcerated recurrent GCT at distal u...
Open access
Research Article10.9734/JCTI/2015/17286
Aims: To present 12 new variants of uracil mustard having drug-like properties and cytotoxic functional group, by utilizing uracil mustard (uramustine) as a lead compound. Utilize rigorous substructure and similarity of a molecular scaffold to determine drug like variants. Physic...
Open access
Research Article10.9734/JCTI/2015/17780
Colon cancer is steadily increasing in Africa with high mortality and it is a pathological consequence of persistent oxidative stress. Kolaviron an active biflavonoid, has been shown to possess antioxidant, anti-lipid peroxidation and chemopreventive properties. The present study...
Open access
Research Article10.9734/JCTI/2015/16809
Various malignancies have been associated with ectopic adrenocorticotropin hormone production causing paraneoplastic Cushing’s syndrome. The most common culprits are small cell lung carcinoma, carcinoid tumors and medullary cancer of the thyroid. Early suspicion and appropriate w...
Open access
Research Article10.9734/JCTI/2015/16817
Aims: To clarify the role of trace elements in the etiology and the pathogenesis of the Ewing's sarcoma, a non-destructive neutron activation analysis with high resolution spectrometry of long-lived radionuclides were performed. Methodology: The silver (Ag), cobalt (Co), chromium...
Open access
Research Article10.9734/JCTI/2015/17464
Primary leiomyosarcoma of the kidney is a rare tumor with an aggressive behavior. However, reported literature is very limited. We report a case of renal leiomyosarcoma in a 46 years old woman presenting with a left sided abdominal mass. Computed tomography scan of the abdomen re...
Open access
Research Article10.9734/JCTI/2015/16798
Aim: The present investigation was aimed at assessing the antiproliferative and apoptotic potential of the hydroalcoholic extract of X. strumarium on HeLa cell line. Study Design: Antitumour activity of Xanthium strumarium was checked by testing against cultured HeLa cells. Place...
Open access
Research Article10.9734/JCTI/2015/15519