Background: Pain, especially chronic pain, remains a major health challenge worldwide. Transient receptor potential (TRP) channels, particularly TRPV1 and TRPA1, play crucial roles in pain perception. Hyaluronic acid (HA), whose bioactivity varies by molecular weight, has shown p...
Open access
Research Article10.9734/jpri/2025/v37i67702
Polystyrene-based microplastics (PS-MPs) induce excessive oxidative stress in testicular tissues. The present study evaluated the role of PS-MP induced oxidative stress on spermatogenesis and consequent fertility in male rats. Five groups of Wistar albino rats, each consisting of...
Open access
Research Article10.9734/jpri/2025/v37i67703
The drug discovery process has been time-consuming and expensive in the past. Also, previous drugs were not formulated as well as the drugs being expected and developed using AI and ML technologies. This article shall elaborate on the stages of drug discovery and development wher...
Open access
Research Article10.9734/jpri/2025/v37i67700
Background: Bronchial asthma is one of the most chronic conditions that affect people of all ages and socioeconomic backgrounds. Bronchial asthma commonly known as Tamaka Shwasa in Ayurveda is a chronic respiratory disorder which is primarily associated with an imbalance of Kapha...
Open access
Research Article10.9734/jpri/2025/v37i67701
Azonwakin Rodrigue Akotegnon, Euloge Oscar Manhognon Faton, Steven Chokki, Fatoumata Bah, Clémentine Michodjehoun, Alphonse Sezan & Lamine Baba-Moussa·Journal of Pharmaceutical Research International·2025
Obesity is often associated with an imbalance in oxidative status, promoting excess free radicals and impairment of endogenous antioxidant systems. This study aimed to evaluate the effects of Ficus umbellata leaf extracts on oxidative stress induced by a high-fat diet in obese Wi...
Open access
Research Article10.9734/jpri/2025/v37i67699
Background: The 35 kDa low-molecular-weight hyaluronic acid (HA35) injection has shown efficacy in alleviating various types of pain, reducing inflammation and edema, and exhibiting potential in lipolysis and cosmetic applications. Compared to injectable forms, oral administratio...
Open access
Research Article10.9734/jpri/2025/v37i57698
Stem cell therapy is an innovative and promising branch of medicine in research nowadays. The therapy uses stem cells, which are capable of developing into different types of cells, to treat injuries and diseases. Stem cell therapy has become a revolutionary area in contemporary...
Open access
Research Article10.9734/jpri/2025/v37i57697
Packiaraj Jeyachandran Manohari, Venkateswaran Chidambaram Seshadri, Induprasad Munirathnam, Aravind Aari Ramesh, Janakiraman Kunchithapatham & Saba Maanvizhi·Journal of Pharmaceutical Research International·2025
Aim: In this research, the pharmaceutical development report of Dexamethasone tablets, 20 mg has been discussed in-detail with all relevant sections in sufficiency thus making it eligible to be filed with a regulatory agency. Scheme: The overall work flow and the report compilati...
Open access
Research Article10.9734/jpri/2025/v37i57696
Background: Cardiovascular diseases encompass a group of conditions affecting the heart and blood vessels. Anticoagulant and antiplatelet medications are commonly prescribed for patients with cardiovascular conditions, including myocardial infarction (heart attack), angina pector...
Open access
Research Article10.9734/jpri/2025/v37i57695
Hadir Gawili, Huda Mohamed, Ahlam Elmetrdi, Amna Elarebi, Laila Elmisalati, Mabrouka Alshikei, Zubida Alshanty, Aya Eissa Al-Baraasi & Fatma El Fargani·Journal of Pharmaceutical Research International·2025
Ventilator associated Pneumonia (VAP) poses a significant challenge in Intensive Care Units (ICUs) of several hospitals, contributing to increased mortality rates, prolonged hospital stays and elevated healthcare cost. Aim: This study aimed to estimate the incidence rate of VAP i...
Open access
Research Article10.9734/jpri/2025/v37i57694