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Research Article Open access CC BY 4.0

A Cross-Sectional Study of the Impact of Antipsychotic Medications on the Hematological Profile of Patients with Schizophrenia in a Tertiary Health Facility in Uyo, South-South, Nigeria

Henry E. Jombo, Timothy A. Ekwere

International Neuropsychiatric Disease Journal · pp. 1–9 · Published 14 Apr 2018

10.9734/INDJ/2018/40894

Abstract

Objective: Antipsychotic drugs have been implicated as a potential cause of haematological toxicity. However, the seemingly mild and asymptomatic presentation is perhaps responsible for it not being frequently investigated. The aim of this study, therefore, was to determine the effect of antipsychotic drugs on the hematological profile of patients with schizophrenia. Methods: This was a descriptive cross-sectional study involving 100 participants i.e. 60 subjects and 40 controls. 2.5 mls of blood was obtained from each participant for determination of full blood counts. Clinical data of subjects including their demographic characteristics, classes of antipsychotics, and duration of antipsychotic usage were obtained from their respective case files. Data was analysed using Statistical Package for Social Sciences for Windows Version 17. Significant level was set at p<0.05. Results: The mean of the hematological parameters including haemoglobin concentration, absolute neutrophil counts and platelet counts were significantly lower among the subjects than the controls p=0.001, 0.04 and 0.001 respectively. Similarly, there was statistically significant differences in the mean platelet count, MPV and PCT of subjects and controls with p<0.001, 0.001 and 0.04 respectively. However, there was no association between the mean age and gender of subjects and absolute neutrophil count p=0.24 and 0.46 respectively. Conclusion: Significant reduction in haematological parameters of subjects compared to the controls may suggest some degree of haemato-toxicity most likely attributable to the antipsychotic drug. Furthermore the absolute neutrophil count though significantly lower in the subjects did not show age or sex differences. Therefore, there is need to regularly monitor haematological indices of psychiatric patients during treatment with antipsychotics.  

Antipsychotics psychiatry neutropaenia blood dyscrasias

References (15)

  1. 1 Prevalence of Metabolic Syndrome and Metabolic Abnormalities in Schizophrenia and Related Disorders—A Systematic Review and Meta-Analysis [DOI]
  2. 2 Neutropenia and Agranulocytosis in Patients Receiving Clozapine in the UK and Ireland [DOI]
  3. 3 Haematological toxicity of drugs used in psychiatry [DOI]
  4. 4 Atypical antipsychotics and metabolic syndrome in patients with schizophrenia: risk factors, monitoring, and healthcare implications.
  5. 5 Prevalence of obesity, glucose homeostasis disorders and metabolic syndrome in psychiatric patients taking typical or atypical antipsychotic drugs: a cross-sectional study [DOI]
  6. 6 Blood Dyscrasias Induced by Psychotropic Drugs [DOI]
  7. 7 Blood dyscrasias in clozapine-treated patients in Italy.
  8. 8 Red Cell Indices
  9. 9 Sudden Late Onset of Clozapine-Induced Agranulocytosis [DOI]
  10. 10 Value of Platelet Indices in Identifying Complete Resolution of Thrombus in Deep Venous Thrombosis Patients [DOI]
  11. 11 Relationship between lipid and hematological profiles with adiposity in obese adolescents [DOI]
  12. 12 Neuroleptic Drug-Induced Changes in Platelet Levels [DOI]
  13. 13 Late Onset Clozapine Induced Agranulocytosis [DOI]
  14. 14 Thrombocytosis due to clozapine treatment: working towards an early marker for clozapine-induced agranulocytosis [DOI]
  15. 15 Cytotoxic activity in serum of patients with clozapine-induced agranulocytosis.

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