A Focus on Fabrication, Characterization, Stability, Skin Targeting, Patent, Safety and Toxicity of Nanostructured Lipid Carrier

Abstract

Background: The advanced development of lipid nanocarrier contributes a lot to the domain of therapeutic effectiveness of the drug. However the parameter such as drug loading, drug release, stability, and targeting influence much more towards the limitation of many lipid nanocarriers. The Nanostructured lipid carrier, the second generation of lipid carrier has more promising advantages over others and have tremendous targeting ability to skin for drug administration. Objective: The present review paper focus to understand the different fabrication technique, impact of lipid and surfactant on formulation effectiveness, characterization of formulation, and Crystalinity concept of lipid which have an impact on stability & drug loading. Focus on a parameter such as Transepidermal water loss , skin occlusion, and hydration which determine the ability of the carrier to target the skin. Hence the effectiveness of the drug improved. This review also focused on patents based on Nanostructured lipid carriers. Method of preparation: many methods have been adopted to prepare Nanostructured lipid carriers and among all High-pressure homogenization method is considered as best one. Conclusion: Because of numerous advantages of this carrier system such as biocompatibility of lipid, high drug encapsulation, stability over others, it is considered as a major focused area for researchers. The new domain of Nanostructured lipid carrier is transdermal drug administration by targeting the skin; hence more research is focused on topical preparation. However, toxicity must have to be studied in humans. So by considering all factors one can rename it as “smart nano lipid carrier".