A Review on Factors and Processing Methods Affecting Antihypertensive Properties of Legumes, and Antihypertensive Properties of Selected Legumes
Tan Wan Xin, Chong Li Choo, Yan See Wan
Asian Food Science Journal · pp. 28–41 · Published 15 Jun 2022
10.9734/afsj/2022/v21i930450Abstract
Hypertension is one of the major risk factors which leads to cardiovascular diseases, and the typical treatment for hypertension is drug therapy. However, as there are side effects to drug therapy, there has been an increase in research on legume proteins as biopeptides have shown antihypertensive effects. Many species of legumes have been cultivated for consumption as they are a good source of protein, carbohydrates, minerals, vitamins, and dietary fiber. Bioactive compounds of legumes potentially improve factors that affect antihypertensive properties, such as angiotensin-converting enzyme (ACE) inhibition activity, renin inhibition activity, and γ-aminobutyric acid (GABA) production. The processing method of enzymatic hydrolysis can improve ACE inhibition activity, as can be seen with horse gram, pigeon pea, and lentil hydrolysates containing potent ACE inhibitory peptides of Thr-Val-Gly-Met-Thr-Ala-Lys-Phe, Val-Val-Ser-Leu-Ser-Ile-Pro-Arg, and Asn-Ser-Leu-Thr-Leu-Pro-Ile-Leu-Arg-Tyr-Leu, while pigeon pea and kidney bean hydrolysates have shown good renin inhibition activity. Fermentation can also be used to process legumes as potent ACE inhibitory peptide Val-Val-Ser-Leu-Ser-Ile-Pro-Arg was identified from fermented pigeon pea, while kidney beans and lentils demonstrated good GABA production through natural fermentation and fermentation with microbial cultures. The germination processing method could also help improve ACE inhibition activity as horse gram has shown good inhibition activity. In vivo study of pigeon pea, kidney bean, and lentils showed potential antihypertensive properties as a significant lowering of systolic blood pressure of test subject was observed. Research done on the structure and function of antihypertensive properties of legumes can help in the development of functional food products which will be beneficial to human health.
References (46)
- 1 Legumes: Importance and Constraints to Greater Use [DOI]
- 2 Nutritional quality of important food legumes [DOI]
- 3 The Renin-Angiotensin Aldosterone System: Pathophysiological Role and Pharmacologic Inhibition [DOI]
- 4 Nutritional and health benefits of pulses [DOI]
- 5 Antihypertensive Peptides from Food Proteins [DOI]
- 6 Food‐Originating ACE Inhibitors, Including Antihypertensive Peptides, as Preventive Food Components in Blood Pressure Reduction [DOI]
- 7 A review of the nutritional value of legumes and their effects on obesity and its related co‐morbidities [DOI]
- 8 Antihypertensive peptides from food proteins: a review [DOI]
- 9 Antioxidant and antihypertensive properties of liquid and solid state fermented lentils [DOI]
- 10 Hypertension: pathophysiology and treatment [DOI]
- 11 Handbook on plant breeding.
- 12 Fermentation enhances the content of bioactive compounds in kidney bean extracts [DOI]
- 13 Basic neurochemistry : principles of molecular, cellular and medical neurobiology
- 14 Bioactive proteins and phytochemicals from legumes: Mechanisms of action preventing obesity and type-2 diabetes [DOI]
- 15 γ-Aminobutyric Acid (GABA): Biosynthesis, Role, Commercial Production, and Applications [DOI]
- 16 Identification, functional gastrointestinal stability and molecular docking studies of lentil peptides with dual antioxidant and angiotensin I converting enzyme inhibitory activities [DOI]
- 17 Reinventing the ACE inhibitors: some old and new implications of ACE inhibition [DOI]
- 18 Effect of soaking and germination on physicochemical and functional attributes of horsegram flour [DOI]
- 19 Effect of solid-state fermentation with Bacillus subtilis lwo on the proteolysis and the antioxidative properties of chickpeas [DOI]
- 20 Antioxidant properties, ACE/renin inhibitory activities of pigeon pea hydrolysates and effects on systolic blood pressure of spontaneously hypertensive rats [DOI]
- 21 The potential of pigeonpea ( Cajanus cajan (L.) Millsp.) in Africa [DOI]
- 22 Extraction of antioxidative and antihypertensive bioactive peptides from Parkia speciosa seeds [DOI]
- 23 Effects of heat treatment and in vitro digestion on the Angiotensin converting enzyme inhibitory activity of some legume species [DOI]
- 24 Phenolic compounds in cowpea and horse gram flours in comparison to chickpea flour: Evaluation of their antioxidant and enzyme inhibitory properties associated with hyperglycemia and hypertension [DOI]
- 25 Influence of Innovative Processing on γ‐Aminobutyric Acid (GABA) Contents in Plant Food Materials [DOI]
- 26 Measuring Angiotensin-I Converting Enzyme Inhibitory Activity by Micro Plate Assays: Comparison Using Marine Cryptides and Tentative Threshold Determinations with Captopril and Losartan [DOI]
- 27 Recent Research in Antihypertensive Activity of Food Protein-derived Hydrolyzates and Peptides [DOI]
- 28 Inhibitory Properties of Kidney Bean Protein Hydrolysate and its Membrane Fractions Against Renin, Angiotensin Converting Enzyme, and Free Radicals
- 29 In vitro renin–angiotensin system inhibition and in vivo antihypertensive activity of peptide fractions from lima bean ( Phaseolus lunatus L.) [DOI]
- 30 Identification and in silico characterization of a novel peptide inhibitor of angiotensin converting enzyme from pigeon pea ( Cajanus cajan ) [DOI]
- 31 Pulses’ germination and fermentation: Two bioprocessing against hypertension by releasing ACE inhibitory peptides [DOI]
- 32 Inhibitory properties of bambara groundnut protein hydrolysate and peptide fractions against angiotensin‐converting enzymes, renin and free radicals [DOI]
- 33 Effect of processing conditions and in vitro protein digestion on bioactive potentials of commonly consumed legumes [DOI]
- 34 Effect of GABA on blood pressure and blood dynamics of anesthetic rats.
- 35 Multifunctional in vitro bioactive properties: Antioxidant, antidiabetic, and antihypertensive of protein hydrolyzates from tarwi ( Lupinus mutabilis Sweet) obtained by enzymatic biotransformation [DOI]
- 36 Silicon supplementation improves the nutritional and sensory characteristics of lentil seeds obtained from drought‐stressed plants [DOI]
- 37 Impact of Elicitation on Antioxidant and Potential Antihypertensive Properties of Lentil Sprouts [DOI]
- 38 Angiotensin-I-converting enzyme inhibitory, antimicrobial, and antioxidant effect of bioactive peptides obtained from different varieties of common beans (Phaseolus vulgaris L.) with in vivo antihypertensive activity in spontaneously hypertensive rats [DOI]
- 39 PROTEIN, FIBRE AND BLOOD PRESSURE: POTENTIAL BENEFIT OF LEGUMES [DOI]
- 40 Lentil-based diets attenuate hypertension and large-artery remodelling in spontaneously hypertensive rats [DOI]
- 41 Evaluation of physicochemical, textural, mineral and protein characteristics of kidney bean grown at Himalayan region [DOI]
- 42 The Function of Renin and the Role of Food-Derived Peptides as Direct Renin Inhibitors [DOI]
- 43 Legume consumption and risk of hypertension in a prospective cohort of Chinese men and women [DOI]
- 44 Antihypertensive Drugs [DOI]
- 45 Lentil polyphenol extract prevents angiotensin II-induced hypertension, vascular remodelling and perivascular fibrosis [DOI]
- 46 Kidney bean protein products as potential antioxidative and antihypertensive alternatives for non-pharmacological inhibition of angiotensin-converting enzymes [DOI]
Cited by 0
No indexed citations yet.
Related research
- Taxonomy of the Rhizobia: Current Perspectives — shares topic coverage
- Development, Evaluation and Safety Aspect of Enriched Weaning Food from Cereal, Legume and Vegetable — shares topic coverage
- Phytochemical, Pasting and Proximate Composition of Improved Weaning Food — shares topic coverage
- Effect of Sorghum-Legume Intercrop on Quality and Rumen Degradability of Sorghum Stover in Adamawa State, Nigeria — shares topic coverage
- Nodulation, Biomass Production and Yield of Some Indigenous Legumes as Influenced by Rhizobium Inoculation in the Rainforest Agro-ecological Zone of Nigeria — shares topic coverage
Article metrics
Real usage data collected on this platform.
50
Page views
0
PDF downloads
8
Outbound clicks
0
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.