Skip to content
Research Article Open access CC BY 4.0

A Review on Neurotoxins from Clostridium botulinum against Neuro-muscular Disorders

Sravani Nalapur, Rangarao Ambati

Journal of Advances in Biology & Biotechnology · pp. 7–14 · Published 17 Aug 2021

10.9734/jabb/2021/v24i730223

Abstract

Neuro-muscular disorders cause a series of serious complications in the human body, where some lead to considerable morbidity and mortality ocassionally. Neurological diseases result in dystrophy, inhibited growth, etc. This present review aimed to emphasize the employment of neurotoxins against neuro degenerative disorders. The source of neurotoxins includes botulinum (Clostridium botulinum), snakes like Vespa orientalis and some medically important arthropods like hornets and spiders. The review not only describes the potential of the neurotoxins in the treatment but also elucidates the mechanism of action of lethal toxins like botulinum. Safety and dosage regimens of various toxins with the help of proven study data would aid in endorsing researchers for further research on toxins making them more superior targeted drugs.

Botulinum Toxins Neuro-muscular Disorders memory palsy

References (19)

  1. 1 Effectiveness of Cholinesterase Inhibitors and Memantine for Treating Dementia: Evidence Review for a Clinical Practice Guideline [DOI]
  2. 2 Functional repair of motor endplates after botulinum neurotoxin type A poisoning: Biphasic switch of synaptic activity between nerve sprouts and their parent terminals [DOI]
  3. 3 Recommendations for the use of botulinum toxin type A in the management of cerebral palsy [DOI]
  4. 4 A Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging Study to Compare the Efficacy and Safety of Three Doses of Botulinum Toxin Type A (Dysport) With Placebo in Upper Limb Spasticity After Stroke [DOI]
  5. 5 A randomized trial of botulinum toxin A for treatment of drooling [DOI]
  6. 6 Botulinum toxin A in the hemiplegia upper limb: a double‐blind trial [DOI]
  7. 7 THE EFFECTS OF BOTULINUM TOXIN ON THE PATTERN OF INNERVATION OF SKELETAL MUSCLE IN THE MOUSE [DOI]
  8. 8 Randomised double blind placebo controlled trial of the effect of botulinum toxin on walking in cerebral palsy [DOI]
  9. 9 Systemic toxicity of botulinum toxin by intramuscular injection in the monkey [DOI]
  10. 10 Botulinum Toxin for Spasticity in Children With Cerebral Palsy: A Comprehensive Evaluation [DOI]
  11. 11 Botulinum toxin: evidence-based medicine criteria in blepharospasm and hemifacial spasm [DOI]
  12. 12 Botulinum toxin: Bioweapon & magic drug [DOI]
  13. 13 Topically Applied Botulinum Toxin Type A for the Treatment of Primary Axillary Hyperhidrosis [DOI]
  14. 14 Single event multilevel botulinum toxin type A treatment and surgery: similarities and differences [DOI]
  15. 15 Diagnostic Uses of Snake Venom [DOI]
  16. 16 Evaluation of the effect of gamma rays on the venom of Vipera lebetina by biochemical study [DOI]
  17. 17 Low-molecular-mass peptides from the venom of the Amazonian viper Bothrops atrox protect against brain mitochondrial swelling in rat: Potential for neuroprotection [DOI]
  18. 18 Botulinum Toxin Treatment on Upper Limb Function in School Age Children With Bilateral Spastic Cerebral Palsy: One Year Follow-up [DOI]
  19. 19 Evaluation of effects of photooxidized Vespa orientalis venom on memory and learning in rats [DOI]

Cited by 0

No indexed citations yet.

Article metrics

Real usage data collected on this platform.

16

Page views

0

PDF downloads

0

Outbound clicks

0

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.