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Research Article Open access CC BY 4.0

A Stroke of Undetermined Source in Geriatrics

Fiammetta Monacelli, Federica Gandolfo, Patrizio Odetti

International Journal of Medical and Pharmaceutical Case Reports · pp. 34–37 · Published 6 Jan 2015

10.9734/IJMPCR/2015/14411

Abstract

Presentation of the Case: Criptogenetic strokes represent a challenge, particularly in geriatrics as the patient’s clinical complexity, the polipharmacotherapy, the epigenetic modifications of a life course may complicate the case clinical presentation and the prognosis. We report the case of a young old woman admitted to hospital for an ischemic stroke recurrence associated to a leg deep venous thrombosis. The medical history was negative for traditional cardiovascular risk factors, excluding a mild carotid atherosclerotic plaque, for rheumatologic/autoimmune or oncological diseases. Haematological malignancies were also ruled out. The coagulative panel showed the prothrombin G202110A gene heterozygote mutation. Discussion: The clinical case adds an interesting narrative frame to the issue of criptogenetic strokes in geriatrics; the mutation of the prothrombin G202110A gene might act synergistically to comorbidity disrupting the atherosclerotic plaque. Immunosenescence, clinical frailty, gender difference and the epigenetic modifications might contribute to stratify a higher pro thrombotic risk for this individual patient. Conclusion: This case strengthens the need to tackle the elderly clinical complexity, through tailored approaches on the single patient.

Criptogenetic strokes elderly frailty cumulative index prothrombin G202110A gene mutation.

References (7)

  1. 1 Frailty in Relation to the Accumulation of Deficits [DOI]
  2. 2 Association between factor V Leiden, prothrombin G20210A, and methylenetetrahydrofolate reductase C677T mutations and events of the arterial circulatory system: a meta-analysis of published studies [DOI]
  3. 3 Hemostasis factors and aging [DOI]
  4. 4 Sex differences in stroke: The contribution of coagulation [DOI]
  5. 5 Cerebrovascular Disease as the Initial Clinical Presentation of Haematological Disorders [DOI]
  6. 6 Ischemic stroke of unusual cause: clinical features, etiology and outcome [DOI]
  7. 7 Borderlines between Sarcopenia and Mild Late-Onset Muscle Disease [DOI]

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