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Research Article Open access CC BY 3.0

Addition of Clidinium-C to the 14-Day Proton Pump Inhibitor Based Triple Therapy for Helicobacter pylori Eradication

Mohammadreza Seyyedmajidi, Saba Homapoor, Elahe Zanganeh, Mohammad Dadjou, Shahab Eskandari Nejad, Mohammad Hadi Tajik Galayeri, Jamshid Vafaeimanesh, Tajik Galayeri

Annual Research & Review in Biology · pp. 4226–4231 · Published 3 Aug 2014

10.9734/ARRB/2014/11357

Abstract

Aims: To assess the effect of clidinium-C on H. pylori eradication with a triple therapy including omeprazole, clarithromycin and amoxicillin (OCA) in patients with peptic ulcer disease (PUD). Also, to investigate the efficacy and safety of clidinium-C in prevention of drugs' side effects. Study Design: Prospective double-blinded randomized clinical trial study. Place and Duration of Study: Department of Internal Medicine, Golestan University of Medical Sciences, from March 2011 to November 2012. Methodology: A total of 200 histopathologically proven H. pylori positive patients with PUD enrolled in this study were randomly assigned to participate in two groups: Group A: a 14-day OCA triple therapy with 20 mg omeprazole bid, 1000 mg amoxicillin bid and 500 mg clarithromycin bid; Group B: a 14-day clidinium-C bid plus OCA triple therapy. Subjects were asked to report any side effects of therapy during the treatment period. A13C-urea breath test was performed for eradication assessment 6 weeks after completion of the treatment. Results: Totally 184 of 200 patients (90 in group A and 94 in group B) could continue the treatment protocols. H. pylori eradication was achieved in 71.1% in Group A (OCA without clidinium-C) and in 72.3% in Group B (OCA with clidinium-C), (p=0.73). The frequencies of abdominal pain and stool abnormality, among the side effects recorded during the therapy period, were significantly lower in group B (OCA with clidinium-C) than in group A (p=0.01 and p=0.001, respectively). Conclusion: Addition of clidinium-C to OCA triple therapy does not increase the H. pylori eradication rates; however, it significantly decreases the frequency of abdominal pain and stool abnormality. This suggests a possibility that the addition of clidinium-C might be an option for increasing the patient's compliance.

Clidinium-C Helicobacter pylori eradication triple therapy proton pump inhibitor

References (11)

  1. 1 Carcinogenesis of Helicobacter pylori [DOI]
  2. 2 Host-Bacterial Interactions in Helicobacter pylori Infection [DOI]
  3. 3 Age-Specific Incidence of Helicobacter pylori [DOI]
  4. 4 A randomized comparison of quadruple and triple therapies for Helicobacter pylori eradication: The QUADRATE study [DOI]
  5. 5 Determinants of Helicobacter pylori infection and chronic gastritis.
  6. 6 Efficacy of probiotics in Helicobacter pylori eradication therapy [DOI]
  7. 7 Review article: the use of biotherapeutic agents in the prevention and treatment of gastrointestinal disease [DOI]
  8. 8 Clarithromycin resistance prevalence and Icea gene status in Helicobacter Pylori clinical isolates in Turkish patients with duodenal ulcer and functional dyspepsia.
  9. 9 Stability-Indicating HPLC Method for Simultaneous Determination of Clidinium Bromide and Chlordiazepoxide in Combined Dosage Forms [DOI]
  10. 10 Probiotic Products in Canada with Clinical Evidence: What Can Gastroenterologists Recommend? [DOI]
  11. 11 Retreatment of helicobacter pylori infection after initial treatment failure [DOI]

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