Skip to content
Research Article Open access CC BY 4.0

Alzheimer's Repairs through the Role of Ketogenic Diet

Asma Saghir Khan, Nazish Zulfiqar, Saliha Naseer, Maryam Iftikhar

International Neuropsychiatric Disease Journal · pp. 1–9 · Published 16 Oct 2023

10.9734/indj/2023/v20i4405

Abstract

Alzheimer's disorder is a devastating neurodegenerative ailment characterized by cognitive decline and reminiscence loss. As the look for powerful treatments continues, researchers have begun investigating the ability of the ketogenic food regimen to manage the signs and symptoms and development of the disease. The ketogenic eating regimen, a low-carbohydrate, high-fat dietary approach, promotes the manufacturing of ketones as an alternative strength supply for the brain. This article affords an overview of the position of the ketogenic weight-reduction plan in Alzheimer's disease and explores its capacity to repair and improve cognitive function in affected people. We discuss the mechanisms behind the ketogenic eating regimen's impact on mind electricity optimization, neuroprotection, insulin sensitivity, and metabolic health. While the ketogenic weight loss program shows promise, its limitations and issues also are discussed, consisting of challenges of adherence and long-term sustainability, ability dietary imbalances, and personal versions. In addition, research is needed to completely apprehend the therapeutic capability of the ketogenic food regimen in Alzheimer's disease and to decide its most fulfilling implementation as part of a comprehensive treatment approach. Alzheimer's disorder (AD) is a progressive neurodegenerative ailment characterized by cognitive decline, memory loss, and impaired everyday functioning. Currently, there's no treatment for the advert, and available remedy options are limited in their efficacy. However, rising proof shows that the ketogenic eating regimen (KD), an excessive-fats, low-carbohydrate dietary technique, may preserve the ability to manage advert or even sell neuronal repair. The metabolic disorder discovered in ad brains, inclusive of decreased glucose metabolism and impaired mitochondrial function, has led researchers to explore opportunities for electricity resources for brain cells. The KD induces a metabolic kingdom called ketosis, where the frame normally relies on ketone our bodies derived from fats as its most important fuel supply. Ketones provide a greater efficient electricity supply to the brain, bypassing the impaired glucose metabolism in advert patients. Research utilizing animal models and early human trials have validated that the KD exerts numerous useful outcomes on advert pathology. Those outcomes include lowering amyloid- beta (Aβ) plaque accumulation, mitigating neuroinflammation, improving mitochondrial characteristics, and promoting the manufacturing of mind-derived neurotrophic component (BDNF), a protein crucial for neuronal increase and survival. Additionally, the KD has been proven to enhance cognitive characteristics and memory in ad sufferers, although further research is wanted to set up its lengthy-term outcomes and protection.

Alzheimer inflammation metabolic Ketogenic Diet (KD) neurodegenerative disorder cognitive neuro inflammation mechanisms therapeutic

References (25)

  1. 1 ApoE in Alzheimer’s disease: pathophysiology and therapeutic strategies [DOI]
  2. 2 The role of mitochondrial dysfunction in Alzheimer's disease pathogenesis [DOI]
  3. 3 Mitochondrial dysfunction in Alzheimer's disease: Role in pathogenesis and novel therapeutic opportunities [DOI]
  4. 4 Ketogenic Diet in Alzheimer’s Disease [DOI]
  5. 5 Effects of a medium-chain triglyceride-based ketogenic formula on cognitive function in patients with mild-to-moderate Alzheimer’s disease [DOI]
  6. 6 Feasibility and efficacy data from a ketogenic diet intervention in Alzheimer's disease [DOI]
  7. 7 Anti-Oxidant and Anti-Inflammatory Activity of Ketogenic Diet: New Perspectives for Neuroprotection in Alzheimer’s Disease [DOI]
  8. 8 Modified ketogenic diet is associated with improved cerebrospinal fluid biomarker profile, cerebral perfusion, and cerebral ketone body uptake in older adults at risk for Alzheimer’s disease: a pilot study [DOI]
  9. 9 The Role of Ketogenic Diet in the Treatment of Neurological Diseases [DOI]
  10. 10 Photodiagnosis and photodynamic therapy
  11. 11 The Therapeutic Role of Ketogenic Diet in Neurological Disorders [DOI]
  12. 12 Medium Chain Triglycerides induce mild ketosis and may improve cognition in Alzheimer’s disease. A systematic review and meta-analysis of human studies [DOI]
  13. 13 Preliminary Report on the Feasibility and Efficacy of the Modified Atkins Diet for Treatment of Mild Cognitive Impairment and Early Alzheimer’s Disease [DOI]
  14. 14 Ketogenic diet prevents chronic sleep deprivation-induced Alzheimer’s disease by inhibiting iron dyshomeostasis and promoting repair via Sirt1/Nrf2 pathway [DOI]
  15. 15 Nutrition and Alzheimer's disease: The detrimental role of a high carbohydrate diet [DOI]
  16. 16 Ketogenic diet rescues cognition in ApoE4+ patient with mild Alzheimer's disease: A case study [DOI]
  17. 17 Medical foods in Alzheimer’s disease [DOI]
  18. 18 Changes in Adiposity and Cerebrospinal Fluid Biomarkers Following a Modified Mediterranean Ketogenic Diet in Older Adults at Risk for Alzheimer’s Disease [DOI]
  19. 19 Can Ketogenic Diet Improve Alzheimer's Disease? Association With Anxiety, Depression, and Glutamate System [DOI]
  20. 20 Microbiota-gut-brain axis: A novel potential target of ketogenic diet for epilepsy [DOI]
  21. 21 Ketogenic Diet as a Promising Non-Drug Intervention for Alzheimer’s Disease: Mechanisms and Clinical Implications [DOI]
  22. 22 Nutritional Ketosis and photobiomodulation remediate mitochondria warding off Alzheimer’s disease in a diabetic, ApoE4+ patient with mild cognitive impairment: A case report [DOI]
  23. 23 Biomarkers, ketone bodies, and the prevention of Alzheimer’s disease [DOI]
  24. 24 Ketogenic diet, high intensity interval training (HIIT) and memory training in the treatment of mild cognitive impairment: A case study [DOI]
  25. 25 Ketogenic therapies in mild cognitive impairment and dementia [DOI]

Cited by 0

No indexed citations yet.

Related research

Article metrics

Real usage data collected on this platform.

24

Page views

0

PDF downloads

4

Outbound clicks

0

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.