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Research Article Open access CC BY 3.0

Ameliorative Effect of Leaves of Carica papaya in Ethanol and Antitubercular Drug Induced Hepatotoxicity

Aashish Pandit, Tarun Sachdeva, Pallavi Bafna

Journal of Pharmaceutical Research International · pp. 648–661 · Published 15 Jun 2013

10.9734/BJPR/2013/4517

Abstract

Aims: The leaves of Carica papaya Linn. (Caricaceae) have been traditionally used as a medicine against some forms of liver diseases. Its hepatoprotective activity against hepatotoxicants like CCl4 and paracetamol has been scientifically proved in animals. The aim of the present study is to examine the hepatoprotective effect of C. papaya leaves against ethanol and anti-tubercular drug-induced liver damage, the two clinically relevant animal models. Study Design: The aqueous extract of leaves of the plant was administered orally to rats and effects on hepatic marker enzymes, tissue antioxidants and liver histology were determined. Place and Duration of Study: The study was performed in Rayat Institute of Pharmacy, Railmajra, Dist. S.B.S. Nagar, Punjab, between Dec’ 2011 to July 2012. Materials and Methods: The study was performed by administering the aqueous extract of C. papaya leaves at the dose of 400 mg/kg in rats prior to administration of ethanol or combination of Isoniazid and Rifampicin. The effects on the levels of serum indicators of liver damage (ALT, AST, alkaline phosphatase and total bilirubin) and tissue antioxidant parameters like TBARS, GSH and SOD were determined. Histopathology of liver was also performed to study the influence of drug on tissue integrity. Results: Hepatoprotective activity of leaves of C. papaya was evident by the significant reduction in the levels of all serum markers in both the models. The extract also significantly increased the levels of SOD, GSH and total protein; and decreased the levels of TBARS, indicating its antioxidant effect. The results obtained were also confirmed by improvements in the histopathology of liver. Conclusion: The results obtained in the current study justify the use of Carica papaya leaves in the prevention of liver damage induced by commonly consumed hepatotoxicants, namely ethanol and anti-tubercular drugs.

Carica papaya leaves ethanol hepatotoxicity antioxidant histopathology

References (24)

  1. 1 PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT [DOI]
  2. 2 Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction [DOI]
  3. 3 The Role of Superoxide Anion in the Autoxidation of Epinephrine and a Simple Assay for Superoxide Dismutase [DOI]
  4. 4 Improved method for the determination of blood glutathione.
  5. 5 Selected major risk factors and global and regional burden of disease [DOI]
  6. 6 Antioxidant Functions of Vitamins [DOI]
  7. 7 Compassionate Cities: Public Health and End-Of-Life Care
  8. 8 Antioxidant and pro-oxidant actions of the plant phenolics quercetin, gossypol and myricetin [DOI]
  9. 9 A text-book of pharmacognosy
  10. 10 The hepatic toxicity of antituberculosis regimens containing isoniazid, rifampicin and pyrazinamide [DOI]
  11. 11 CYP2E1 mediated isoniazid-induced hepatotoxicity in rats.
  12. 12 Triterpene Saponins from Vietnamese Ginseng (Panaxvietnamensis) and Their Hepatocytoprotective Activity [DOI]
  13. 13 Protective effects of mycelia of Antrodia camphorata and Armillariella tabescens in submerged culture against ethanol-induced hepatic toxicity in rats [DOI]
  14. 14 Protective effects of silymarin, a milk thistle (Silybium marianum) derivative on ethanol-induced oxidative stress in liver.
  15. 15 Hispolon Protects against Acute Liver Damage in the Rat by Inhibiting Lipid Peroxidation, Proinflammatory Cytokine, and Oxidative Stress and Downregulating the Expressions of iNOS, COX-2, and MMP-9 [DOI]
  16. 16 Hepatoprotective Influence of Vitamin C on Thioacetamide-induced Liver Cirrhosis in Wistar Male Rats [DOI]
  17. 17 Hepatoprotective Activity of Bombax ceiba Linn against Isoniazid and Rifampicin-induced Toxicity in Experimental Rats
  18. 18 Effect of Dried Fruits of Carica papaya LINN on Hepatotoxicity. [DOI]
  19. 19 The Aqueous Seed Extract Of Carica papaya Linn. Prevents Carbon Tetrachloride Induced Hepatotoxicity In Rats
  20. 20 Hepatoprotective and some haematological effects of Allium sativum and vitamin C in lead-exposed wistar rats [DOI]
  21. 21 Hepatoprotective effect of Liv. 52 on antitubercular drug-induced hepatotoxicity in rats
  22. 22 Acute Ethanol Intoxication Inhibits Neutrophil beta2-Integrin Expression in Rats During Endotoxemia [DOI]
  23. 23 Effects of phenolic compounds on bromobenzenemediated hepatotoxicity in mice [DOI]
  24. 24 Hepatoprotective Effect of Silymarin Against Hepatotoxicity Induced by Anti‐tubercular Drugs in Malnourished Rats [DOI]

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