Skip to content
Research Article Open access CC BY 4.0

An Investigation on Some Hepatic Enzymes and Haematological Variables among Alcoholic Volunteers in Kadima District of Jos South Local Government Area of Plateau State, Nigeria

Yohanna Denkok, Vincent Gambo Linus, Kehinde F. Oyebade, Abara S. Ukeme, Samuel Y. Gazuwa, Ishaya Y. Longdet

Journal of Applied Life Sciences International · pp. 30–40 · Published 4 Sep 2021

10.9734/jalsi/2021/v24i530236

Abstract

Aim: This research work investigated the impact of the differences in duration of alcoholic beverage consumption on hepatic and heamatological parameters. Methods: Fifty (50) healthy male volunteer subjects were recruited for this study from Kadima district of Jos South Local Government Area of Plateau State, Nigeria and were coded according to the years of alcohol consumption: 1-7, 8-14, 15-21, and 22-28 for groups B, C, D and E respectively with each having ten (10) volunteers. Group A was christened as the control having human subjects that have neither drank Burukutu nor factory- based lager beer. Full blood count was done using haematology analyser while spectrophometric method was used to assay for the activities of AST, ALT, ALP, GGT as well as various levels/concentrations of TB, DB, TP, urea and creatinine. Results: Result obtained showed that AST and ALP were raised (p < 0.05) in all the groups when compared to the control. ALT was elevated in group E only while GGT was increased (p < 0.05) in groups D and E. Total and direct bilirubin were both elevated (p < 0.05) in groups B, C and E but equal control in group D. Total protein was higher in groups B and C but lowered in groups D and E relative control. Concentrations of urea was statistically significant (p < 0.05) in groups C and E. Creatinine was only statistically significant in group C but equal control in other groups. Results of the haematological parameters showed that RBC and WBC were reduced in all the groups’ relative control. Hb concentration was increased (p < 0.05) in groups C, D and E. PCV was found to be reduced in groups B, C and D when compared to the control. Conclusion: This study has shown that prolong ingestion of local brew impacts negatively on hepatic biomarkers as well as some haematological indexes like WBC, RBC and PCV.

Burukutu brew factory-based beer alcoholism liver enzyme

References (13)

  1. 1 The Genetic Basis of the Reduced Expression of Bilirubin UDP-Glucuronosyltransferase 1 in Gilbert's Syndrome [DOI]
  2. 2 Prediction of risk of liver disease by alcohol intake, sex, and age: A prospective population study [DOI]
  3. 3 Risk factors for hepatocellular carcinoma: Synergism of alcohol with viral hepatitis and diabetes mellitus [DOI]
  4. 4 Molecular Mechanisms of Alcoholic Fatty Liver [DOI]
  5. 5 Characteristics of African traditional beers brewed with sorghum malt: a review
  6. 6 Role of Alcohol in Liver Carcinogenesis [DOI]
  7. 7 Alcoholic foamy degeneration—A pattern of acute alcoholic injury of the liver [DOI]
  8. 8 Serum Activity of Mitochondrial Aspartate Aminotransferase: A Sensitive Marker of Alcoholism With or Without Alcoholic Hepatitis [DOI]
  9. 9 Zinc Toxicity Following Massive Coin Ingestion [DOI]
  10. 10 Protective role of caffeic acid against alcohol‐induced biochemical changes in rats [DOI]
  11. 11 Organic Metabolites, Alcohol Content, and Microbial Contaminants in Sorghum-based Native Beers Consumed in Barkin Ladi Local Government Area, Nigeria [DOI]
  12. 12 Identifying the alcoholic.
  13. 13 THE EFFECT OF ALCOHOL INTOXICATIONS ON HEMATOLOGICAL PARAMETERS OF ADULT ALBINO WISTAR RATS

Cited by 2

(untitled)

· The Indonesian Journal of General Medicine · 2025

What is the relationship between chronic alcohol consumption and liver function markers in adult ? : A Systematic Review

Nevan Bayu Sunggoro · The Indonesian Journal of General Medicine · 2025

Related research

Article metrics

Real usage data collected on this platform.

51

Page views

0

PDF downloads

10

Outbound clicks

2

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.