Anti-Diarrhoea Property of Crude Aqueous Leave Extract of Red Apple Psidium guajava in Castor Oil-Induced Diarrhoea in Rats
Okere O. Shekins, Iliemene Uju Dorathy
Journal of Pharmaceutical Research International · pp. 2694–2701 · Published 19 Nov 2014
10.9734/BJPR/2014/13297Abstract
Objective: To investigate the anti-diarrhoea property of aqueous leaves extract of Psidium guajava (red apple guava leaves) in castor oil-induced diarrhoea in rats. Methods: Five groups of five rats each orally received the following treatment; groups II, III & IV received 100, 200 & 400 mg/kg body weight of the extract respectively and group V received a standard drug for diarrhoea (Laperamide), while group 1 received 1ml of castor oil only without treatment. 1 ml of castor oil was given to rats in all groups, one hour after the treatment with extract and standard drug. The rats in each group were then placed singly in a cage with adsorbent paper on the floor of the cage. The diarrhoea episode was observed for 4 hours and the cumulative frequency of the wet and formed stools were noted at the end of the 4th hour. Percentage inhibition of diarrhoea was calculated using the mean stool frequency and the anti-diarrhoea activity determined in terms of percentage protection. Results: The extract reduced stooling in castor oil induced diarrhoea in rats in group IV which shows no significant difference with the group V treated with standard drug. The rats in group I showed the highest stooling episode which is significantly higher than all other groups. Conclusion: These findings suggest that an aqueous extract of guava leaves may be used as an effective treatment for non specific diarrhoea in medicine. The anti-diarrhoea action may be linked to direct inhibitory effect of the extract on the propulsive movement of the gastrointestinal tract smooth muscles. It equally shows that the treatment is dose dependent.
References (19)
- 1 Phytochemical constituents of some Nigerian medicinal plants [DOI]
- 2 Effect of washing hands with soap on diarrhoea risk in the community: a systematic review [DOI]
- 3 Psidium guajava: A review of its traditional uses, phytochemistry and pharmacology [DOI]
- 4 Morphology and Evolution of Vascular Plants [DOI]
- 5 In vitro Antimicrobial Activity and Phytochemical Analysis of Some Indian Medicinal Plants
- 6 Study of antidiarrhoeal activity of four medicinal plants in castor-oil induced diarrhoea [DOI]
- 7 Delay of castor oil diarrhoea in rats: a new way to evaluate inhibitors of prostaglandin biosynthesis [DOI]
- 8 Anti-Inflammatory and analgesic effects of Psidium guajava Linn. (myrtaceae) leaf aqueous extracts in rats and mice [DOI]
- 9 Effects of Prostaglandins, Theophylline, and Cholera Exotoxin Upon Transmucosal Water and Electrolyte Movement in the Canine Jejunum [DOI]
- 10 Inhibition of gastrointestinal release of acetylchoune byquercetin as a possible mode of action of Psidium guajava leaf extracts in the treatment of acute diarrhoeal disease [DOI]
- 11 Dissociation of castor oil‐induced diarrhoea and intestinal mucosal injury in rat: effect of NG‐nitro‐L‐arginine methyl ester [DOI]
- 12 Antidiarrhoeal effects of Ocimum gratissimum leaf extract in experimental animals [DOI]
- 13 Ricinoleic acid: Current view of an ancient oil [DOI]
- 14 Antidiabetic activity of an ethanol extract obtained from the stem bark of Psidium guajava (Myrtaceae).
- 15 Chronic diarrhea: a review on pathophysiology and management for the clinical gastroenterologist [DOI]
- 16 Mechanism of action of castor oil: a biochemical link to the prostaglandins.
- 17 In vivo antioxidant and hepatoprotective effects of methanolic extract of dioclea reflexa seed in rats following acute or chronic liver injury [DOI]
- 18 Hepatotoxic effects of chloroform extract of Artemisia macivera Linn in rats following intraperitoneal administration of different subchronic doses [DOI]
- 19 Acidic Lipids: Prostaglandins [DOI]
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