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Research Article Open access CC BY 4.0

Antioxidant Activities of Phycocyanin: A Bioactive Compound from Spirulina platensis

Gamal A. Gabr, Salwa M. El-Sayed, Mohamed S. Hikal

Journal of Pharmaceutical Research International · pp. 73–85 · Published 16 Mar 2020

10.9734/jpri/2020/v32i230407

Abstract

Background and Objectives: The cyanobacterium Spirulina also called blue green algae is a class of gram negative bacteria which possesses wide range of bioactive colored components as Phycocyanin, carotenoids and chlorophyll. Spirulina is one of the microalgae containing nutrients that have been used as a functional food in addition to therapeutic and pharmaceutical applications. This study aimed to evaluate the biochemical composition of Spirulina platensis biomass and its ethanolic and aqueous extracts, as well as, evaluate the antioxidant activities of the biomass, ethanolic, aqueous and the purified Phycocyanin. Materials and Methods: The chemical compositions of Spirulina platensis were determined, as well as the antioxidant activity of extracts, Phycocyanin, Phycocyanopeptide and Phycocyanobilin using (DPPH) radical-scavenging activity. Results: Results show that biomass has higher total proteins (49.72±0.508%), total carbohydrates (10.3±0.330%), moisture content (7.5±0.685%), lipids (7.2±0.105%) and Minerals (6.9±0.130%). In biomass, the total phenols (51.20±0.25 µg/mL) and flavonoids (97.73±1.858 µg/mL) were high compared to the ethanolic (49.48±0.130 and 69.07±1.814 µg/mL) and aqueous (15.27±0.639 and 4.67±0.611 µg/mL) extracts respectively. In the phenolic compounds, pyrogallol was identified as the major compound in biomass and aqueous extract (63.85 and 12.33%) respectively, E-vanillic acid in ethanolic (18.20 %), whereas, hespirdin (3.517 and1.639%) were major flavonoids found in aqueous and ethanolic extracts respectively. The DPPH scavenging activity was found higher in ethanolic extract compared to aqueous while in bioactive, the order of antioxidant activity was Phycocyanin > Phycocyanobilin > Phycocyanopeptide. Conclusions: The study data regarding to Spirulina nutritional value, makes Spirulina an excellent choice when formulating diets and combating malnutrition. Furthermore, it is a strong antioxidant and could be used as alternative treatments as anticancer, antidiabetic, and anti-inflammatory agent.

Spirulina platensis antioxidants chemical composition phycocynin.

References (23)

  1. 1 The antioxidant, immunomodulatory, and anti-inflammatory activities of Spirulina: an overview [DOI]
  2. 2 Antioxidant composition and activity of barley (Hordeum vulgare) and malt extracts and of isolated phenolic compounds [DOI]
  3. 3 OTAL PHENOLICS AND TOTAL FLAVONOIDS IN BULGARIAN FRUITS AND VEGETABLES
  4. 4 Screening for bioactive compounds from algae [DOI]
  5. 5 Antioxidant activity of the microalga Spirulina maxima [DOI]
  6. 6 Production of biomass and nutraceutical compounds by Spirulina platensis under different temperature and nitrogen regimes [DOI]
  7. 7 Chlorogenic acid modifies plasma and liver concentrations of: cholesterol, triacylglycerol, and minerals in (fa/fa) Zucker rats [DOI]
  8. 8 Antioxidant capacities of the selenium nanoparticles stabilized by chitosan [DOI]
  9. 9 Potential pharmacological applications of polyphenolic derivatives from marine brown algae [DOI]
  10. 10 Phycocyanin and phycocyanobilin from Spirulina platensis protect against diabetic nephropathy by inhibiting oxidative stress [DOI]
  11. 11 Role of pH on antioxidants production by Spirulina ( Arthrospira ) platensis [DOI]
  12. 12 Methods of Analysis and Quantification of Phenolic Compounds [DOI]
  13. 13 FACTORS THAT EFFECT ANTIOXIDANT ACTIVITY OF C-PHYCOCYANINS FROM SPIRULINA PLATENSIS [DOI]
  14. 14 Nicotinamide overload may play a role in the developmentof type 2 diabetes [DOI]
  15. 15 Wound healing potential of Spirulina platensis extracts on human dermal fibroblast cells [DOI]
  16. 16 Production of the α and β Subunits of Spirulina Allophycocyanin and C-Phycocyanin in Escherichia coli: A Comparative Study of Their Antioxidant Activities [DOI]
  17. 17 Improvement of Stability and Antioxidant Activities by Using Phycocyanin - Chitosan Encapsulation Technique [DOI]
  18. 18 Spirulina: possible pharmacological evaluation for insulin-like protein [DOI]
  19. 19 In vitro effects of cinnamic acid derivatives on protein tyrosine phosphatase 1B [DOI]
  20. 20 Role of Spirulina platensis in the control of glycemia in DM2 rats
  21. 21 Antioxidant Profile of Spirulina: A Blue-Green Microalga [DOI]
  22. 22 EFFECT OF COMBINATION OF TWO PLANT EXTRACTS ON DIABETES MELLITUS [DOI]
  23. 23 Effects of pioglitazone on atherogenic risk predictor indices of alloxan-induced diabetic rabbits [DOI]

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