Skip to content
Research Article Open access CC BY 4.0

Apo Lipoproteins A1 and B in Multidrug-Resistant Tuberculosis (MDR-TB)

Bahi Gnogbo Alexis, Bamba Abou, Aké-Edjème Angèle, N’Guessan A. Jean Luc, Kouman A. Augustine, Djaman Allico Joseph

International Journal of Biochemistry Research & Review · pp. 62–69 · Published 1 Apr 2024

10.9734/ijbcrr/2024/v33i4870

Abstract

Aims: The medical management of multidrug-resistant tuberculosis (MDR-TB) has become a major public health issue. Apolipoproteins play a key role in lipoprotein metabolism such as the recognition of receptors involved in lipoprotein metabolism. Thus, the study of the inter- relationships between apolipoproteins (A1 and B) and MDR-TB could represent an important approach to the biological management of MDR-TB patients. Methodology: This is an experimental study carried out on eighty-two (82) patients including thirty-eight (38) MDR-TB patients which age ranged from 18 to 60 years old recruited from three tuberculosis centers (CAT) in the city of Abidjan and forty-four (44) non-tuberculosis patients used as control aged 18 to 60 years old recruited at the National Blood Transfusion Center (CNTS) in Treichville (Abidjan, Côte d’Ivoire). Total cholesterol, HDL-cholesterol and triglycerides were measured by the colorimetric-enzymatic method. Apolipoproteins A1 and B were measured using the immunoturbidimetric method. Results and Conclusion: Showed a dyslipidemia concerning cholesterol and its HDL fraction, triglycerides and apolipoproteins A1 and B suggest an atherogenic profile in multidrug-resistant TB patients.

MDR-TB apolipoproteins lipids Abidjan Côte d’Ivoire

References (17)

  1. 1 Estimation of the Concentration of Low-Density Lipoprotein Cholesterol in Plasma, Without Use of the Preparative Ultracentrifuge [DOI]
  2. 2 Lipids, lipoproteins, and apolipoproteins as risk markers of myocardial infarction in 52 countries (the INTERHEART study): a case-control study [DOI]
  3. 3 Foamy Macrophages from Tuberculous Patients' Granulomas Constitute a Nutrient-Rich Reservoir for M. tuberculosis Persistence [DOI]
  4. 4 Lipid-Related Markers and Cardiovascular Disease Prediction [DOI]
  5. 5 Hypocholesterolemia is a significant predictor of death in a cohort of chronic hemodialysis patients [DOI]
  6. 6 Comparison of Conventional Lipoprotein Tests and Apolipoproteins in the Prediction of Cardiovascular Disease [DOI]
  7. 7 Mycobacterium tuberculosis and lipids: Insights into molecular mechanisms from persistence to virulence [DOI]
  8. 8 A Cholesterol-Rich Diet Accelerates Bacteriologic Sterilization in Pulmonary Tuberculosis [DOI]
  9. 9 Discovery and identification of serum potential biomarkers for pulmonary tuberculosis using iTRAQ‐coupled two‐dimensional LC‐MS/MS [DOI]
  10. 10 Screening and identification of five serum proteins as novel potential biomarkers for cured pulmonary tuberculosis [DOI]
  11. 11 Serum HDL-C levels, log (TG/HDL-C) values and serum total cholesterol/HDL-C ratios significantly correlate with radiological extent of disease in patients with community-acquired pneumonia [DOI]
  12. 12 Tuberculosis treatment raises total cholesterol level and restores high density lipoprotein cholesterol (HDL-C) in patients with pulmonary tuberculosis [DOI]
  13. 13 Serum lipids as biomarkers for therapeutic monitoring of latent tuberculosis infection [DOI]
  14. 14 Isoniazid-Induced Reduction of Serum Cholesterol [DOI]
  15. 15 Reliability of lipid, lipoprotein, and apolipoprotein measurements.
  16. 16 Apolipoproteins: Biochemistry, methods and clinical significance [DOI]
  17. 17 LIPID PROFILES AND LIPOPROTEIN (A) IN PULMONARY TUBERCULOSIS PATIENTS

Cited by 0

No indexed citations yet.

Article metrics

Real usage data collected on this platform.

51

Page views

0

PDF downloads

6

Outbound clicks

0

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.