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Research Article Open access CC BY 4.0

Appraising the Neurobehavioural Toxicity Potential of Aqueous Methanol Leaf Extract of Tapinanthus globiferus Growing on Azadirachta indica

A. M. Umarudeen, M. G. Magaji

International Neuropsychiatric Disease Journal · pp. 1–11 · Published 4 Jul 2020

10.9734/indj/2020/v14i230123

Abstract

The high prevalence and disease burden of anxiety disorders against the paucity and liabilities of existing anxiolytics indicates a need for the discovery of additional/new anti-anxiety agents. However, it is necessary to further screen these new/putative anxiolytic compounds/extracts to rule out the unwanted neurobehavioural toxicities inherent in the existing anti-anxiety drugs. Aqueous methanol leaf extract of Tapinanthus globiferus growing on Azadirachta indica host tree has previously demonstrated significant (p<0.05) anxiolytic effects in mice. This study, therefore, set out to counter-screen this extract for locomotion-suppressant, acute amnesic, sedative (myorelaxant) and hypnotic effects using standard mouse behavioural and biochemical paradigms. The leaf extract (150, 500 and 1500 mg/kg) did not cause significant (p>0.05) alterations in spontaneous locomotor activity, motor coordination/balance, sleep onset or duration, but dose-dependent and significant (p<0.05) increases (63.28±5.63, 65.63±4.12 and 69.18±3.69) in novel object recognition indices of extract-treated compared to 51.54±4.03 and 61.06±2.91 scores in diazepam- and aqua-treated mice, respectively. These findings indicate the aqueous methanol leaf extract is mostly devoid of the evaluated neurobehavioural toxicities and may possess short-term memory enhancement property in mice. These findings may justify the traditional use of Tapinanthus globiferus extracts for memory enhancement.

Cognitive effects hypnotic locomotor mice sedative suppressant

References (32)

  1. 1 Use of the Open Field Maze to Measure Locomotor and Anxiety-like Behavior in Mice [DOI]
  2. 2 Administration of substances to laboratory animals: routes of administration and factors to consider.
  3. 3 SSRI Antidepressant Medications [DOI]
  4. 4 Measuring Motor Coordination in Mice [DOI]
  5. 5 Lifetime and 12-month prevalence of mental disorders in the Nigerian Survey of Mental Health and Well-Being [DOI]
  6. 6 Benzodiazepine harm: how can it be reduced? [DOI]
  7. 7 Withdrawing Benzodiazepines in Primary Care [DOI]
  8. 8 Addressing the Side Effects of Contemporary Antidepressant Drugs: A Comprehensive Review [DOI]
  9. 9 Benzodiazepines: Risks and benefits. A reconsideration [DOI]
  10. 10 Overview of Diagnosis and Drug Treatments of Anxiety Disorders [DOI]
  11. 11 The mouse beam walking assay offers improved sensitivity over the mouse rotarod in determining motor coordination deficits induced by benzodiazepines [DOI]
  12. 12 African mistletoes (loranthaceae); ethnopharmacology, chemistry and medicinal values: An update [DOI]
  13. 13 Genetic variance of laboratory outbred Swiss mice [DOI]
  14. 14 Sedative properties of the decoction of the rhizome of Cyperus articulatus [DOI]
  15. 15 Evaluation of the hypoglycemic effect and antioxidant activity of three Viscum album subspecies (European mistletoe) in streptozotocin-diabetic rats [DOI]
  16. 16 Minimizing Cardiovascular Adverse Effects of Atypical Antipsychotic Drugs in Patients with Schizophrenia [DOI]
  17. 17 Cognitive Function before and during Treatment with Selective Serotonin Reuptake Inhibitors in Patients with Depression or Obsessive-Compulsive Disorder [DOI]
  18. 18 Therapeutic potential of mistletoe in CNS-related neurological disorders and the chemical composition of Viscum species [DOI]
  19. 19 Adverse Drug Reaction Monitoring of Antidepressants in the Psychiatry Outpatients Department of a Tertiary Care Teaching Hospital [DOI]
  20. 20 The Ethnobotanical, Phytochemical and Mineral Analyses of Phragmanthera Incana (Klotzsch), A Species of Mistletoe Growing on Three Plant Hosts in South-Western Nigeria [DOI]
  21. 21 Enhancing Spatial Memory: Anxiolytic and Antidepressant Effects ofTapinanthus dodoneifolius(DC) Danser in Mice [DOI]
  22. 22 Mirtazapine [DOI]
  23. 23 Occurrence of the lutein-epoxide cycle in mistletoes of the Loranthaceae and Viscaceae [DOI]
  24. 24 Use of benzodiazepines in the treatment of anxiety.
  25. 25 Ethno-botanical survey of medicinal plants used for the management of depression by Hausa tribes of Kaduna State, Nigeria [DOI]
  26. 26 Evaluation of the Antidepressant-like Activity of the Crude Extract and Solvent Fractions of Rosa Abyssinica Lindley (Rosaceae) Using Rodent Models of Depression [DOI]
  27. 27 Phytochemical and Some Neuropharmacological Studies on the Methanolic Leaf Extracts of Cissus cornifolia [Vitaceae] in Mice [DOI]
  28. 28 Phytochemical Screening and Anticonvulsant Activity of the Residual Aqueous Fraction of Tapinanthus globiferus Growing on Ficus glums [DOI]
  29. 29 Antioxidant and antikindling effect of Tapinanthus globiferus growing on Ficus glumosa in pentylenetetrazole induced kindled rats [DOI]
  30. 30 Preliminary phytochemical and antimicrobial activity screening of crude extracts of bird lime (Tapinanthus globiferus) [DOI]
  31. 31 The pharmacology of anxiolytics [DOI]
  32. 32 Sedative and anticonvulsant evaluation of Tapinanthus globiferus A. Rich (Loranthaceae) in mice and chicks [DOI]

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