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Research Article Open access CC BY 4.0

Assessment of Interleukin 6 and C-reactive Protein as Inflammatory Markers among Patients with Substance Use Disorder in Federal Neuropsychiatric Hospital, Kaduna

S. Y. Olatunbosun, B. O. P. Musa, A. J. Yusuf, O. R. Obiakor, A. A. Elfulaty

International Neuropsychiatric Disease Journal · pp. 1–13 · Published 30 Mar 2020

10.9734/indj/2019/v13i3-430115

Abstract

Aim: This research aimed to determine the relationship between substance use disorder (SUD) and the biomarkers of inflammation: (C-reactive protein: CRP and Interleukin-6: IL-6) to investigate inflammatory reaction among SUD patients. Study Design: This is a cross sectional comparative study. Place and Duration of Study: This study was conducted at Federal Neuro-Psychiatric Hospital (FNPH) Kaduna, North-western Nigeria which serve as a referral center for patients with psychiatric disorders from all the North Western states and the Federal Capital Territory, Abuja between August 2018 and August 2019. Methodology: The study population was drawn from SUD patients who were positive to urine drug test. The serum CRP and IL-6 levels of 180 SUD patients (study group) were compared with the serum CRP and IL-6 levels of 180 apparently normal individuals who do not have history of substance abuse. Results: The median and interquartile range of the ages of both the study group and the control group were 30 (23 – 40) and 33.5 (24-41) years respectively. The study population consist of 162 (90%) males and 18 (10%) females with median ages and range of 30.5 (15 – 72) and 26 (14 – 40) years respectively. A significant increase in IL-6 in SUD was observed (P = .0001) but no significant difference observed in CRP at 95% confidence interval (P = .73). It was observed that there was a strong positive relationship between IL-6 and CRP (r = 0.6646); P = .0001) in SUD patients. Conclusion: IL-6 was significantly higher in people with SUD and as CRP levels increases IL-6 increases. This suggests that there is a level of inflammatory reaction in substance use disorder patients. Thus both serum CRP and IL-6 level can be considered as biomarkers of inflammation in patients with SUD.

Interleukin inflammatory markers substance use disorder drug use disorder.

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