Asymmetric Dimethylarginine Level in Children Undergoing Bone Marrow Transplantation
Dina Maher Ahmad, Eslam E. Elhawary, Gamal Alden Fathy, Hala Mohamed Nagy, Ibrahim Mohamed Bedraya, Mohamed Ramadan Elshanshory
Journal of Advances in Medicine and Medical Research · pp. 10–14 · Published 3 Jun 2022
10.9734/jammr/2022/v34i1931430Abstract
Background: Asymmetric dimethylarginine (ADMA) is a toxic, non‐proteinogenic amino acids formed by post‐translational modification and is a uremic toxin that inhibits nitric oxide (NO) production. The aim of this work was to assess the serum level of asymmetric dimethylarginine in children underwent bone marrow transplantation. Methods: This prospective, randomized controlled study has been conducted on 20 children aged 2-18 years underwent bone marrow transplantation (Group I) and 20 healthy control children of matched age and sex (group II). Results: The serum level of ADMA was significantly higher after bone marrow transplantation (p value <0.05). Conclusions: Elevated ADMA level after bone marrow transplantation indicates that endothelial dysfunction is a main complication in those patients.
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