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Research Article Open access CC BY 4.0

Bioactive Compounds of the Salivary Glands from Aedes aegypti with Anti-Hemostatic Action

Bruno Marcel Silva de Melo, Norma Luciene Lima da Silva, Rafaelli de Souza Gomes, Kely Campos Navegantes, Ana Lígia de Brito Oliveira, Lorena Almeida, Carolina Heitmann Mares Azevedo, Marta Chagas Monteiro

Annual Research & Review in Biology · pp. 1–17 · Published 24 Aug 2015

10.9734/ARRB/2015/20322

Abstract

Blood-sucking arthropods evolved a salivary cocktail of anti-hemostatic, platelet antiaggregant and vasodilators components that neutralize the effects of hemostasis and allow a successful blood supply occurs. In salivary glands from Aedes aegypti was found several components with anti-hemostatic action that inhibit the platelet aggregation and coagulation. These anticoagulants can prevent clot formation during the ingestion and digestion of blood meals by the Ae. aegypti insect. Thus, this review focused in Ae. aegypti saliva components that have anticlotting action and that has potential sources of novel pharmacologically active molecules, as potential therapeutic of new cardiovascular and anti-thrombotic drugs.

Aedes aegypti salivary bioactive compounds blood clotting anti-hemostatic.

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