Breast Cancer Molecular Subtypes in Relation to Age, Stage and Grade among Sudanese Women Patients in Khartoum Oncology Hospital (2013 – 2017)

Abstract

Background: There is a lack of data regarding molecular subtypes of breast cancer among Sudanese female patients. Moreover to the best of our knowledge no study had correlated the molecular subtypes with age, stage and grade till date. This study aimed to determine breast cancer molecular subtypes among Sudanese women in relation to age, clinical stage and grade and to compare the findings to other related researches. Methods: Retrospective Study of (255) Sudanese female patients diagnosed with breast cancer from September 2013 to August 2017 in Khartoum Specialized Oncology Center, an information sheet was used to collect data from patients medical records. Results: The results demonstrated that, the most commonly detected molecular subtype was luminal B (34.9%), followed by triple negative and HER-2 enriched, (31.4%) and (19.2%) respectively. The least common subtype was luminal A, (14. 5%). Additionally, over half of the patients (54.4%) were classified as grade 3 and (22.4%) were diagnosed as stage IIIb. Conclusion: The main conclusion that can be drawn is that, luminal B was the most commonly diagnosed subtype and it was more common in younger age group in comparison to luminal A. The majority of the patients in the study were grade 3 and stage IIIb and were diagnosed between the age of 41 and 50. Moreover, triple negative subtype was high among Sudanese women and was associated with advance grade breast cancer.