Carcinoid Heart Disease: A Review
Thiago Andrade Macedo, Roberto Nery Dantas Júnior, Ismar Aguiar Marques Filho, Pedro Gabriel Melo de Barros e Silva, Liliane Gomes da Rocha, Bernardo Baptista da Cunha Lopes, Marcio Campos Sampaio
Journal of Advances in Medicine and Medical Research · pp. 1–10 · Published 13 May 2016
10.9734/BJMMR/2016/25952Abstract
Carcinoid tumors are rare malignancies able to spread and produce bioactive humoral products, mainly serotonin, which is responsible for the Carcinoid Syndrome (CS); its features are: flushing, diarrhea, bronchospasm and valvular heart disease. The Carcinoid Heart Disease (CHD) importantly worsens prognosis and it is found in up to 50% of patients with CS. After being produced by liver implants, serotonin finds its way straight into the right heart cavities, leading to valve tissue aggression and ventricular dysfunction. Early CHD diagnosis is still a challenge due to the asymptomatic initial stage, until right heart failure develops along with ascites, swelling and hepatomegaly. Echocardiography is still the main tool for diagnosis, especially due to its ability to appropriately evaluate ventricular and valve function, cardiac morphology and hemodynamics. Tricuspid regurgitation, pulmonic stenosis and dilated cardiomyopathy are the main impairments found in CHD. Magnetic resonance imaging has also developed well in this field, and it is now believed to be essential, due to accurate right cavities evaluation and fibrosis detection. For better prognosis, early diagnosis must be pursued, which has impact on clinical management and valve repair surgical decision.
References (43)
- 1 A 5‐decade analysis of 13,715 carcinoid tumors [DOI]
- 2 68Ga-DOTA-Tyr3-Octreotide PET in Neuroendocrine Tumors: Comparison with Somatostatin Receptor Scintigraphy and CT [DOI]
- 3 Octreotide Acetate Long-Acting Formulation Versus Open-Label Subcutaneous Octreotide Acetate in Malignant Carcinoid Syndrome [DOI]
- 4 Detection of somatostatin receptors in surgical and percutaneous needle biopsy samples of carcinoids and islet cell carcinomas.
- 5 Factors Associated with Progression of Carcinoid Heart Disease [DOI]
- 6 Long-Term Serotonin Administration Induces Heart Valve Disease in Rats [DOI]
- 7 Current knowledge on diagnosis and staging of neuroendocrine tumors [DOI]
- 8 Risk Factors for the Development and Progression of Carcinoid Heart Disease [DOI]
- 9 Treatment of the carcinoid syndrome with the longacting somatostatin analogue lanreotide: a prospective study in 39 patients. [DOI]
- 10 Features of Carcinoid Heart Disease Identified by 2- and 3-Dimensional Echocardiography and Cardiac MRI [DOI]
- 11 Usefulness of N-terminal Pro–Brain Natriuretic Peptide as a Biomarker of the Presence of Carcinoid Heart Disease [DOI]
- 12 Metastatic carcinoid tumor to the heart: echocardiographic-pathologic study of 11 patients [DOI]
- 13 Chromogranin-A and N-Terminal Pro-Brain Natriuretic Peptide: An Excellent Pair of Biomarkers for Diagnostics in Patients With Neuroendocrine Tumor [DOI]
- 14 Surgical Management of Left-Sided Carcinoid Heart Disease [DOI]
- 15 Ultra-High-Dose Lanreotide Treatment in Patients with Metastatic Neuroendocrine Gastroenteropancreatic Tumors [DOI]
- 16 Prediction of prognosis by echocardiography in patients with midgut carcinoid syndrome [DOI]
- 17 Cardiovascular complications of malignant carcinoid disease [DOI]
- 18 Carcinoid Heart Disease [DOI]
- 19 The Association of a Panel of Biomarkers with the Presence and Severity of Carcinoid Heart Disease: A Cross-Sectional Study [DOI]
- 20 Early and Late Results of Valvular Surgery for Carcinoid Heart Disease [DOI]
- 21 A Matter of the Heart: Myocardial Metastases in Neuroendocrine Tumors [DOI]
- 22 Current Concepts in Diagnosis and Perioperative Management of Carcinoid Heart Disease [DOI]
- 23 Role of natriuretic peptides in the diagnosis and treatment of patients with carcinoid heart disease [DOI]
- 24 Carcinoid heart disease: impact of pulmonary valve replacement in right ventricular function and remodeling [DOI]
- 25 Bioprosthetic tricuspid valve stenosis associated with extensive plaque deposition in carcinoid heart disease [DOI]
- 26 Carcinoid Heart Disease: Impact of Pulmonary Valve Replacement in Right Ventricular Function and Remodeling [DOI]
- 27 Carcinoid heart disease [DOI]
- 28 Effects of ondansetron on gastrointestinal symptoms in carcinoid syndrome [DOI]
- 29 Role of Hepatic Resection for Patients With Carcinoid Heart Disease [DOI]
- 30 Role of Hepatic Resection for Patients With Carcinoid Heart Disease [DOI]
- 31 Magnetic Resonance Imaging Diagnosis of Carcinoid Heart Disease [DOI]
- 32 Cardiovascular magnetic resonance imaging in the assessment of carcinoid heart disease [DOI]
- 33 Carcinoid heart disease: Early failure of an allograft valve replacement [DOI]
- 34 Surgical Management of Left-Sided Carcinoid Heart Disease [DOI]
- 35 MRI and CT revealing carcinoid heart disease [DOI]
- 36 Carcinoid heart disease and carcinoid syndrome: successful surgical treatment [DOI]
- 37 Carcinoid Heart Disease in Patients Without Hepatic Metastases [DOI]
- 38 Three-dimensional visual guidance improves the accuracy of calculating right ventricular volume with two-dimensional echocardiography [DOI]
- 39 New and Emerging Treatment Options for Gastroenteropancreatic Neuroendocrine Tumors.
- 40 Magnetic Resonance Imaging of Carcinoid Heart Disease [DOI]
- 41 Cardiac carcinoid: tricuspid delayed hyperenhancement on cardiac 64-slice multidetector CT and magnetic resonance imaging [DOI]
- 42 New images in carcinoid heart disease [DOI]
- 43 The American Joint Committee on Cancer: the 7th Edition of the AJCC Cancer Staging Manual and the Future of TNM [DOI]
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