Characterization of ABO / Rhesus Antigen Polymorphism Associated with Malaria in a Malaria Hotspot in Bayelsa State, Niger Delta, Nigeria
Faith Ajiebabhio Ogbole, Chidi Uzoma Igwe, Henrietta Chinyere Onuoha, Chiamaka Perpetua Nzebude
International Journal of Biochemistry Research & Review · pp. 42–52 · Published 4 Sep 2023
10.9734/ijbcrr/2023/v32i7826Abstract
Aim: The aim of the present study was to characterize the role of ABO/Rhesus blood group antigen polymorphism in malaria among adults in Bayelsa State, Niger Delta, Nigeria. The pattern of distribution of ABO/Rhesus antigen polymorphism in the area was also assessed. Materials and Methods: Two hundred and six adults (91 males and 115 females) were randomly selected for the study and they were examined for the presence of malaria parasite infection and illness as well as for type of ABO/Rhesus antigen polymorphism using real time PCR-high resolution melting analysis, clinical malaria indicators and agglutination methods respectively. The density of malaria parasitemia was evaluated using microscopy and socio-demographic variables were collected using a structured questionnaire. Multinomial logistics regression and one way ANOVA tests were used to assess the difference between frequencies and means, respectively. Results: Showed that the distribution of ABO/Rhesus antigen polymorphism were in the following order: blood group O, 50% (O+ 47.57%; O- 2.43%), blood group B, 21.36% (B+, 20.39%; B-, 0.97%), blood group A, 18.93% (A+, 18.93%, A-, 0%), and blood group AB (AB+, 9.71%, AB-, 0%). Among severe malaria subjects, ABO antigen polymorphism distribution were A, 29%; B, 57%; AB, 5% and O, 10%. Among mild malaria subjects, ABO antigen polymorphism distribution were A, 36%; B, 33%; AB, 23% and O, 8%. Among asymptomatic malaria subjects, ABO antigen polymorphism distribution were A, 12%; B, 12%; AB, 7% and O, 69% of the subjects respectively. Among uninfected subjects, ABO antigen polymorphism distribution were A, 20%; B, 20%; AB, 7% and O, 53%. Each ABO blood group antigen was associated with asymptomatic malaria, while blood group A, B, and AB were associated with mild malaria and only blood group B was associated with severe malaria (P < 0.05). Parasite density showed no association with ABO Blood group. Conclusion: ABO blood group antigen polymorphism was associated with malaria. Blood group O conferred protection against mild and severe malaria, while blood group B conferred susceptibility to severe malaria. Prevention and treatment of malaria in relation to ABO blood groups is implicated in the present study.
References (20)
- 1 How to Calculate Sample Size for Different Study Designs in Medical Research? [DOI]
- 2 “Asymptomatic” Malaria: A Chronic and Debilitating Infection That Should Be Treated [DOI]
- 3 Human ABO Blood Groups and Their Associations with Different Diseases [DOI]
- 4 Gender difference in the incidence of malaria diagnosed at public health facilities in Uganda [DOI]
- 5 Development of High Resolution Melting Analysis for the Diagnosis of Human Malaria [DOI]
- 6 Distribution of ABO and Rh (D) Blood groups in India: A systematic review [DOI]
- 7 Comparison of methods for detecting asymptomatic malaria infections in the China–Myanmar border area [DOI]
- 8 ABO Blood System and COVID-19 Susceptibility: Anti-A and Anti-B Antibodies Are the Key Points [DOI]
- 9 High malaria parasitemia among outpatient febrile children in low endemic area, East-Central Tanzania in 2013 [DOI]
- 10 Asymptomatic and sub-microscopic Plasmodium falciparum infection in children in the Mount Cameroon area: a cross-sectional study on altitudinal influence, haematological parameters and risk factors [DOI]
- 11 The Effect of ABO Blood Groups, Hemoglobinopathy, and Heme Oxygenase-1 Polymorphisms on Malaria Susceptibility and Severity [DOI]
- 12 Assessing ABO/Rh Blood Group Frequency and Association with Asymptomatic Malaria among Blood Donors Attending Arba Minch Blood Bank, South Ethiopia [DOI]
- 13 Prevalence of Malaria Parasite among Asymptomatic Primary School Children in Angiama Community, Bayelsa State, Nigeria [DOI]
- 14 Association of Undiagnosed Pre-Diabetes and Type-2 Diabetes Mellitus with Interleukin-2 mRNA Expression Among Adults in Bayelsa State, Nigeria [DOI]
- 15 Distribution of Body Mass Index and Abdominal Obesity in Bayelsa State with Associated Interleukin-2 Gene Expression [DOI]
- 16 Upregulation of Interleukin-2 Among Hypertensive Subjects in Bayelsa State, Nigeria [DOI]
- 17 Evaluating the Prevalence of Malaria Parasite Infection among Adults in Wetlands Using Nested PCR and High Resolution Melting Analysis [DOI]
- 18 Application of High-Resolution Melting (HRM) Technique Towards the Detection of Asymptomatic Malaria in a Malaria Endemic Area of Southeastern Iran Under Elimination Program [DOI]
- 19 Galvanizing Communities towards Zero Malaria in Nigeria: An Account of 2019 World Malaria Day in Bayelsa State [DOI]
- 20 Asymptomatic and Sub-microscopic Plasmodium Falciparum Infection in Children in the Mount Cameroon Area: a Cross-sectional Study on Altitudinal Influence, Haematological Parameters and Risk Factors [DOI]
Cited by 3
F. Ogbole, C. U. Igwe, C. Onuoha · Scientific African · 2024
F. Ogbole, A. Ogbuta, H. I. Okagbue · BMC Environmental Science · 2024
Showing 2 of 3 known citations — external sources report more than can currently be individually listed.
Related research
- ABO Blood Groups and Malaria Prevalence in a Referral Hospital in Nigeria — shares topic coverage
- Prevalence of Malaria among Pregnant Women and Children Under Five Years in Abi Local Government Area, Cross River State, Nigeria — shares topic coverage
- A Study on Relationship of Thrombocytopenia and Likelihood of Severe Malaria in Patients Admitted With Malaria in a Tertiary Care Hospital of Dakshina Kannada — shares topic coverage
- Platelet Alteration in Plasmodium vivax Malaria Patients in Thailand — shares topic coverage
- Patients’ Perception of Health Care Services in Malaria Endemic Area in Mali: Villages with Health Care Services Versus villages Without Health Care Services — shares topic coverage
Article metrics
Real usage data collected on this platform.
50
Page views
0
PDF downloads
15
Outbound clicks
3
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.