Comparative Analysis of Bone Regenerative Potential of Simvastatin Vs Platelet Rich Plasma in Mandibular Third Molar Extraction Socket: A Study Protocol

Abstract

Background: Third Molar Extraction is a treatment used by oral and maxillofacial surgeons in which distal bone loss to the second molar is a major concern due to consequences such as pain, mastication difficulty, and pocket development. Platelet -Rich Plasma (PRP), a novel adjunct to promote bone regeneration. The method of its preparation is cumbersome and need a costly centrifuge machine. Hence many studies have been conducted to find an effective alternative to Autologous PRP. Statins have also proved effective in inducing bone regeneration of which Simvastatin has been more effective.It can also be used in immediate implant cases where faster and better bone healing is necessary for osseointegration. Aim: To assess the effectiveness of simvastatin and PRP in regenerating bone in third molar extraction sockets. Materials and Methods: All together 15 patients will be selected with identical bilateral third molar impaction. All the patients will be divided into two groups of simvastatin and PRP. Expected Results: If the results prove significant, Simvastatin can be used as an osteoinductive agent for bone healing. Conclusion: If the outcomes favor the bone regeneration potential of Simvastatin to be equivalent or superior than PRP, then Simvastatin can be used for osteoinduction in Third Molar Extraction socket or other small bony defects.