Comparative Effects of Garcinia kola and Garlic Extracts on Some Liver and Haematological Functions in High Salt Diet-Induced Hypertensive Wistar Rats
Chigozirim A. Osuji, Achi Ngozi Kalu, Ohaeri Christopher Obioma, Ohiagu Chukwuemeka John
International Journal of Biochemistry Research & Review · pp. 1–10 · Published 1 Feb 2024
10.9734/ijbcrr/2024/v33i2853Abstract
Garcinia kola is commonly consumed in Nigeria in social ceremonies, while Garlic is commonly used as a spice in the preparation of certain foods. In this study, the protective effects of extracts of the plants against a high salt diet (8% NaCl) induced hypertension were investigated in rats. Extracts prepared from the plants were subjected to phytochemical screening for acute and sub-acute toxicity studies in rats. In the protective study against salt-induced hypertension thirty-five adult male rats assigned to seven groups of five rats were treated such that, group one served as the normal control group, and group two was the hypertensive control group. Groups three to six were administered graded doses of extracts respectively after induction. While group seven received a combination of the two extracts after induction. Treatment commenced after confirmation of hypertension and lasted for two weeks before animals were sacrificed to collect blood for biochemical and haematological analysis. Results obtained showed that G.kola and Garlic feeding produced in rats following liver and haematological assays as values of these parameters in the test groups did not significantly differ from control values (p<0.05).
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