Comparison of Efficacy of Preloading With 0.9% Normal Saline with Premptive Dose of Ephedrine for Attenuation of Hemodynamic Response during Propofol Induction
Journal of Pharmaceutical Research International · pp. 15–18 · Published 15 Dec 2021
10.9734/jpri/2021/v33i58B34164Abstract
Two different regimes propofol-normal saline vs propofol -ephedrine in prevention of hypotension during induction of anaesthesia, significant decrease in Systolic blood pressure (P<0.001) in both groups (both fluid and non-fluid groups) after induction of anaesthesia with propofol was observed. The incidence of hypo-tension was significant in control and crystalloid group when compared with ephedrine group. Systolic blood pressure decreased in all three groups and decrease in Systolic blood pressure at 2min, 3min and 5min with P values. 0.010, 0.00, 0.000 respectively. Also decrease in Mean Arterial pressure in P group when compared with E-group at 1, 2, 3, 4, and 5min with P values 0.038, 0.02, 0.012 and 0.029 respectively.
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