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Research Article Open access CC BY 4.0

Comparison of Intravenous and Topical Injection Administration Mesenchymal Stem Cell Secretome to Restrain Gastrointestinal Anastomosis Leakage: A Review

Joko Wibowo Sentoso, Agung Putra, Ida Bagus Budhi SA, Anung Noto Nugroho, Suryo Wahyu Raharjo

International Research Journal of Gastroenterology and Hepatology · pp. 1–8 · Published 10 Jan 2025

10.9734/irjgh/2025/v8i1107

Abstract

Intestinal anastomosis is one of the most commonly performed gastrointestinal surgical procedures, especially in emergencies and is commonly performed in elective procedures when resection is performed for benign or malignant lesions of the gastrointestinal tract. One of the important postoperative complications that causes significant morbidity and adversely affects the length of hospital stay is anastomotic leak after gastrointestinal anastomosis. Recently, developments in regenerative medicine applied to gastrointestinal anastomoses show promise for improving anastomotic healing. Recent studies have demonstrated that stem cell-derived secretomes can potentially enhance anastomized tissue regeneration without the safety and ethical limitations of stem cell transplantation. A study showed that the MSC secretome significantly promoted cell proliferation and survival in a dose-dependent manner and resulted in the controlled release of growth factors. Mesenchymal stem cell (MSC)-derived secretomes have controlled delivery of bioactive factors, and have potential in improving healing of intestinal anastomoses. In this review, we discuss the comparison of the therapeutic effects of the MSC secretome given by topical injection and the MSC secretome injected intravenously in terms of healing and anastomotic resistance.

Mesenchymal stem cells mesenchymal stem cells secretome intestinal anastomosis leakage anastomotic resistance

References (17)

  1. 1 Definition and grading of anastomotic leakage following anterior resection of the rectum: A proposal by the International Study Group of Rectal Cancer [DOI]
  2. 2 Estimated need for surgery worldwide based on prevalence of diseases: a modelling strategy for the WHO Global Health Estimate [DOI]
  3. 3 Combined Preoperative Mechanical Bowel Preparation With Oral Antibiotics Significantly Reduces Surgical Site Infection, Anastomotic Leak, and Ileus After Colorectal Surgery [DOI]
  4. 4 The Burden of Gastrointestinal Anastomotic Leaks: an Evaluation of Clinical and Economic Outcomes [DOI]
  5. 5 Risk factors and outcomes associated with anastomotic leaks following esophagectomy: a systematic review and meta-analysis [DOI]
  6. 6 Umbilical cord‐derived mesenchymal stem cell secretome promotes skin regeneration and rejuvenation: From mechanism to therapeutics [DOI]
  7. 7 Mesenchymal Stem Cell Secretome for Dermatology Application: A Review [DOI]
  8. 8 Polymeric Hydrogels as Mesenchymal Stem Cell Secretome Delivery System in Biomedical Applications [DOI]
  9. 9 Effect of indocyanine green fluorescence angiography on preventing anastomotic leakage after colorectal surgery: a meta-analysis [DOI]
  10. 10 Adipose-tissue-derived Stem Cells Enhance the Healing of Ischemic Colonic Anastomoses: An Experimental Study in Rats [DOI]
  11. 11 APPLICATION OF MULTIPOTENT MESENCHYMAL STEM CELL SECRETOME IN THE TREATMENT OF ADJUVANT ARTHRITIS AND CONTACT-ALLERGIC DERMATITIS IN ANIMAL MODELS [DOI]
  12. 12 Mesenchymal stem cell secretome-loaded fibrin glue improves the healing of intestinal anastomosis [DOI]
  13. 13 Stem cell therapy applied for digestive anastomosis: Current state and future perspectives [DOI]
  14. 14 Minimally invasive versus open oesophagectomy for patients with oesophageal cancer: a multicentre, open-label, randomised controlled trial. [DOI]
  15. 15 Formulation of secretome derived from mesenchymal stem cells for inflammatory skin diseases [DOI]
  16. 16 The Role of Adipose Tissue Mesenchymal Stem Cells in Colonic Anastomosis Healing in Inflammatory Bowel Disease: Experimental Study in Rats [DOI]
  17. 17 Adipose derived mesenchymal stem cells in gastrointestinal system anastomosis: a narrative review [DOI]

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