Could Monocytes Colonized by Circulating Epithelial Cells of the Prostate Gland be a Source of Metastasis of the Adenocarcinoma? A Hypothesis Based on a Previous Study
Mramba Nyindo, Abdul- Hamid Lukambagire, Lucy Mimano
Journal of Cancer and Tumor International · pp. 1–5 · Published 11 Aug 2016
10.9734/JCTI/2016/28227Abstract
Background: Recently we reported the successful in vitro cultivation of prostatic epithelial and stromal cells from patients with benign prostatic hyperplasia and adenocarcinoma of the prostate by liquid biopsy. In that study we noticed monocytes that were colonized by prostatic epithelial cells; this was confirmed using a monoclonal antibody to prostate epithelial cells. We also detected a deleterious effect exerted on the monocyte cytoplasm by a process yet to be determined. Aim: To develop a hypothesis that will explain the significance of monocytes colonized by prostatic epithelial cells in the pathogenesis of prostate adenocarcinoma. Study Design: Retrospective analysis of images in the previous study. Place and Duration: Kilimanjaro Christian Medical University College, Tumaini University, Moshi, Tanzania. One month. Results: We found that all monocytes viewed, without exception, contained intra-cytoplasmic prostatic epithelial cells and most of them presented with apparent cytopathology. The cytopathology presented as strand formation and shrinkage of monocytes. Often the loss of integrity of monocyte cytoplasm could be arbitrarily graded as little to complete loss of cytoplasm. Conclusion: We hypothesize that epithelial cells invade monocytes and colonize the cytoplasm. Monocytes colonized by epithelial cells then participate in the metastatic process of the prostate adenocarcinoma to different parts of the body. We report for the first time, a monocyte colonized by an epithelial cell of the prostate gland. This could also be an unrecognized phenomenon with other types of cancers.
References (10)
- 1 Immune Regulation of Cancer [DOI]
- 2 CCL2 is a Potent Regulator of Prostate Cancer Cell Migration and Proliferation [DOI]
- 3 Pathogenesis of osteoblastic bone metastases from prostate cancer [DOI]
- 4 Emerging roles of chemokines in prostate cancer [DOI]
- 5 CX3CR1 Is Expressed by Prostate Epithelial Cells and Androgens Regulate the Levels of CX3CL1/Fractalkine in the Bone Marrow: Potential Role in Prostate Cancer Bone Tropism [DOI]
- 6 Tropical Canine Pancytopenia: in Vitro Cultivation of the Causative Agent—Ehrlichia canis [DOI]
- 7 Inflammatory Blood Monocytes Contribute to Tumor Development and Represent a Privileged Target To Improve Host Immunosurveillance [DOI]
- 8 Understanding and Targeting Osteoclastic Activity in Prostate Cancer Bone Metastases [DOI]
- 9 Role of monocyte‐lineage cells in prostate cancer cell invasion and tissue factor expression [DOI]
- 10 Circulating Prostate Gland Cells in Benign Prostatic Hyperplasia and Adenocarcinoma in Patients of African Heritage: Diagnosis by Liquid Biopsy: Preliminary Results [DOI]
Cited by 0
No indexed citations yet.
Related research
- Fracture of the Humeral Bone as the First Clinical Presentation of Metastatic Papillary Thyroid Carcinoma in Ibadan — shares topic coverage
- Rare Presentation of Metastatic Papillary Thyroid Carcinoma with Cribiform Type in Pelvic Bones — shares topic coverage
- The E1 Copper Binding Domain of Full-Length Amyloid Precursor Protein Promotes Epithelial to Mesenchymal Transition in DU145 Cells in an Isoform-Specific Manner — shares topic coverage
- Inhibition of Mmp-9 Expression through Nf-Kβ by Natural Compounds as a Possible Therapeutic Adjuvant Strategy in Breast Cancer: A Systematic Review — shares topic coverage
- The Adrenal Gland as a Rare Metastatic Site of Oesophageal Carcinoma: A Case Report — shares topic coverage
Article metrics
Real usage data collected on this platform.
35
Page views
0
PDF downloads
4
Outbound clicks
0
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.