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Research Article Open access CC BY 4.0

CoVid-19 Pandemic: An Update Clinical Features, Diagnostic Methods, Drugs and Vaccine Race

Théophile Uwiringiyeyezu, Bouchra El Khalfi, Rachid Saile, Jamal Belhachmi, Abdelaziz Soukri

Annual Research & Review in Biology · pp. 96–109 · Published 17 Sep 2020

10.9734/arrb/2020/v35i930282

Abstract

CoViD-19 pandemic is a viral disease caused by SARS-COV-2virus and since December 2019, has spread rapidly in all the world countries; At the end of June 2020, over 10 million peoples were infected in the world and more than 500,000 deaths have been identified. Due to its fast transmission, the unavailability of drugs and vaccines and the asymptomatic patients who still spread the virus various measures were implemented to stop this virus. The studies were carried out to identify the molecular characteristics, transmission methods, origins, and all other clinical parameters necessary to eradicate it. The results have shown that CoViD-19 can be transmitted either animal-to-person or person-to-person by airborne. On March 11, 2020, world health organization (WHO) declared the CoViD-19 a pandemic, there, every concerned country has made the different health measures to stop the virus spread; the confirmed CoViD-19 patient undergoes the validation medicals diagnostics tests to follow specific treatments as time goes staying in quarantine room of the hospital to keep away from contact with others. To treat this pandemic, the world of medicine has tried with previous treatments of other viruses with encouraging results but of course, with doubts about the success of the therapeutic effectiveness and the scientific researches continue until the development of the therapeutic medicine and the Covid-19 specific vaccine. Today, the use of anti-inflammatory drugs was reported like chloroquine/hydroxychloroquine, the antiviral drugs like ritonavir, Lopinavir, ribavirin, and remdesivir and also the glycocorticoids hormones like dexaméthasone to the patients with severe CoViD-19. Different strains of this coronavirus infect humans, bats, and other mammals. Two strains of VOC-SARS have caused outbreaks of severe respiratory disease in humans: VOC-SARS, which caused an outbreak of severe acute respiratory syndrome (SARS) between 2002 and 2003, and VOC-SARS-2, which since late 2019 has caused a coronavirus disease pandemic 2019 (COVID-19). Even if today, there are not validated CoViD-19 drugs or vaccines. In This paper, we will talk about what we know until today on SARS-COV-2 and CoViD-19 pandemic particularly the clinical symptoms, transmissions ways, biological samples concerned by SARS-COV-2 infection, medicals laboratories parameters in CoViD-19 cases, medication and medicine and molecular diagnostics methods.

Severe acute respiratory syndrome coronavirus 2 Diagnostic methods CoViD-19 Polymerase chain reaction Reverse-transcription loop-mediated isothermal amplification molecular diagnosis biological samples diagnostic methods medicals analysis clinical features.

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